Skip to main content
DeutschDE
European Commission logo print header

In-cell NMR monitoring of alpha-Synuclein aggregation in neuronal cells

Ziel

Intracellular aggregation of the human amyloid protein alpha-synuclein is causally involved in Parkinson’s disease, a debilitating neurodegenerative disorder. The goal of this project is to combine low-resolution, fluorescence-imaging methods with high-resolution in-cell NMR and EPR spectroscopy techniques to derive macroscopic and microscopic insights into alpha-synuclein aggregate structures directly in neuronal cells.

To achieve this goal, we will employ different sets of cultured neurons and investigate intracellular alpha-synuclein aggregation under defined conditions of mitochondrial dysfunction and cellular oxidative stress, two of the most common denominators of the disease. Importantly, we will also establish a human stem cell model for studying alpha-synuclein aggregation with high-resolution in-cell NMR and EPR methods, by using induced pluripotent stem cell (iPSC) derived dopaminergic neurons from Parkinson’s disease patients and control individuals.

Results from this study will provide novel insights into the native mechanisms of intracellular aggregate formation and ultimately enable novel pharmacological approaches for therapeutic intervention.

Wissenschaftliches Gebiet

Schlüsselbegriffe

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

ERC-2014-CoG

Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

ERC-COG - Consolidator Grant

Gastgebende Einrichtung

WEIZMANN INSTITUTE OF SCIENCE
Netto-EU-Beitrag
€ 1 143 821,37
Adresse
HERZL STREET 234
7610001 Rehovot
Israel

Auf der Karte ansehen
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 1 143 821,37

Begünstigte (2)

Diese Seite teilen

Herunterladen

Letzte Aktualisierung: 7 Juli 2023

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/647474/de

European Union, 2024