Cel Horizontal gene transfer (HGT) is a form of genic inheritance that occurs between individuals in a population or between species rather than from parent to offspring. HGT is most prevalent in bacteria, where it is an important source of novel metabolic pathways, pathogenicity factors, and antibiotic resistance.In spite of the importance of HGT, we understand little about the evolutionary barriers to HGT. This proposal will outline a systematic experimental approach to elucidate factors that select for or against horizontally transferred genes, by pursuing three objectives. The first is to quantify intrinsic selection acting on newly transferred genes, by experimentally transferring and expressing several hundred genes across species boundaries. We will be able to systematically classify genes as resistant or permissive to transfer, examine the effect of the function and position in metabolic and regulatory networks on resistance to transfer, as well as identify any genes with substantial intrinsic benefits. The second objective is to examine the effect of evolutionary divergence on HGT, by determining whether genes from closely related species are more permissive to transfer than those from more divergent species. The final objective is to determine the role of the environment in shaping these selective effects. Understanding how robust the selective effects are to different environmental conditions will aid in evaluating the relative roles of genetics and the environment as factors in the evolutionary outcomes of HGT . Overall, this work will provide a systematic analysis of the roles of different factors in affecting the outcomes of horizontal gene transfer. Understanding this process in a quantitative fashion is critical to understanding bacterial adaptation and diversity. Dziedzina nauki natural sciencesbiological sciencesgeneticsmedical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistancenatural sciencescomputer and information sciencesdata sciencedata processing Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-CoG-2014 - ERC Consolidator Grant Zaproszenie do składania wniosków ERC-2014-CoG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-COG - Consolidator Grant Instytucja przyjmująca THE UNIVERSITY OF LIVERPOOL Wkład UE netto € 1 515 740,95 Adres BROWNLOW HILL 765 FOUNDATION BUILDING L69 7ZX Liverpool Zjednoczone Królestwo Zobacz na mapie Region North West (England) Merseyside Liverpool Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 515 740,95 Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko THE UNIVERSITY OF LIVERPOOL Zjednoczone Królestwo Wkład UE netto € 1 515 740,95 Adres BROWNLOW HILL 765 FOUNDATION BUILDING L69 7ZX Liverpool Zobacz na mapie Region North West (England) Merseyside Liverpool Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 515 740,95 INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Zakończenie uczestnictwa Austria Wkład UE netto € 305 124,05 Adres Am Campus 1 3400 Klosterneuburg Zobacz na mapie Region Ostösterreich Niederösterreich Wiener Umland/Nordteil Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 305 124,05