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H2020

CONQUER

Project ID: 665172
Financé au titre de

Contrast by Quadrupole Enhanced Relaxation

De 2015-09-01 à 2018-08-31, projet en cours | CONQUER Site web

Détails concernant le projet

Coût total:

EUR 2 463 975

Contribution de l'UE:

EUR 2 463 975

Coordonné à/au(x)/en:

Austria

Appel à propositions:

H2020-FETOPEN-2014-2015-RIASee other projects for this call

Régime de financement:

RIA - Research and Innovation action

Objectif

Deliverables

  • Quantum-mechanical model 1

    An NQR-modeling approach which has been developed for solids will be extended towards different motional scenarios to account for rotational, translational and internal dynamics as well as exchange processes. Existing numerical tools will be used for initial simulations but the software will be continuously developed to account for the complex relaxation scenario. Optimisation is likely to be required as the computational complexity increases significantly for high spin (9/2) nuclei. Where necessary, the quantum-mechanical models will be combined with molecular dynamics simulations.

  • Scientific papers of reporting period 1

    3 Scientific papers planned on theoretical modelling, synthesis of NQR-CR compounds and their characterisation.

  • NQR-CR polymers characterised

    Immobilisation of the most promising candidates from WP3 in terms of NQR frequencies onto PEG differing in molecular weight and the degree of branching. The immobilisation will be performed by reacting the Bi compounds bearing a functional spacer group (e.g. carboxylic groups) with the polymers. For example, carbodiimide chemistry is a well-known procedure for coupling OH with COOH groups in a very efficient way, and several literature procedures are known. Purification (e.g. dialysis) of the polymers and nanoprecipitation under sonication conditions to create nano- and micro-particles with defined sizes according to the guidelines WP2 from UWM and UU. The sizes will be varied over two orders of magnitudes in order to explore the influence on relaxivity. Characterisation of the NPs by state of the art techniques (Infrared spectroscopy, SWAXS, TEM, dynamic light scattering, zeta potential, ZF-NQRS, fast field cycling relaxometry).

  • Webpage with open access database

    Design and implementation of a webpage for communicating general information and results, providing open access to data and for facilitating networking activities.

Publications

  • Novel smart MRI contrast agents based on nuclear quadrupole cross relaxation – pre-selection of promising compounds
    Author(s): C. Gösweiner; R. Fischer; M. Schlögl; D. Kruk; A. Petrovic; S. Spirk; H. Scharfetter
    Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, issue ESMRMB Congress, September 2016, Volume 29, Supplement 1, 2016. Page(s) 247–400.  ISSN: 0968-5243
    DOI: 10.5281/zenodo.159270
  • NOVEL POLYSACCHARIDE-BASED NANOPARTICLES AND THEIR POTENTIAL APPILCATION IN biomedical IMAGING
    Author(s): Božič Mojca, Bračič Matej, Doris Tkaučič, Silvo Hribernik, Manja Kurečič, Kargl Rupert, Spirk Stefan, Mohan Tamilselvan, Stana-Kleinschek Karin

Coordinateur

TECHNISCHE UNIVERSITAET GRAZ
Austria

Contribution de l'UE: EUR 1 231 250


RECHBAUERSTRASSE 12
8010 GRAZ
Austria
Activity type: Higher or Secondary Education Establishments

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Participants

UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE
Poland

Contribution de l'UE: EUR 472 500


UL. OCZAPOWSKIEGO 2
10 719 OLSZTYN
Poland
Activity type: Higher or Secondary Education Establishments

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UNIVERZA V MARIBORU
Slovenia

Contribution de l'UE: EUR 584 125


SLOMSKOV TRG 15
2000 MARIBOR
Slovenia
Activity type: Higher or Secondary Education Establishments

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UMEA UNIVERSITET
Sweden

Contribution de l'UE: EUR 83 750


UNIVERSITETOMRADET
901 87 UMEA
Sweden
Activity type: Higher or Secondary Education Establishments

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MEDIZINISCHE UNIVERSITAT GRAZ
Austria

Contribution de l'UE: EUR 92 350


AUENBRUGGERPLATZ 2
8036 GRAZ
Austria
Activity type: Higher or Secondary Education Establishments

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