Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

H2020

CONQUER

Project ID: 665172
Finanziato nell'ambito di

Contrast by Quadrupole Enhanced Relaxation

Dal 2015-09-01 al 2018-08-31, progetto in corso

Dettagli del progetto

Costo totale:

EUR 2 463 975

Contributo UE:

EUR 2 463 975

Coordinato in:

Austria

Invito a presentare proposte:

H2020-FETOPEN-2014-2015-RIASee other projects for this call

Meccanismo di finanziamento:

RIA - Research and Innovation action

Obiettivo

Deliverables

  • Quantum-mechanical model 1

    An NQR-modeling approach which has been developed for solids will be extended towards different motional scenarios to account for rotational, translational and internal dynamics as well as exchange processes. Existing numerical tools will be used for initial simulations but the software will be continuously developed to account for the complex relaxation scenario. Optimisation is likely to be required as the computational complexity increases significantly for high spin (9/2) nuclei. Where necessary, the quantum-mechanical models will be combined with molecular dynamics simulations.

  • Scientific papers of reporting period 1

    3 Scientific papers planned on theoretical modelling, synthesis of NQR-CR compounds and their characterisation.

  • NQR-CR polymers characterised

    Immobilisation of the most promising candidates from WP3 in terms of NQR frequencies onto PEG differing in molecular weight and the degree of branching. The immobilisation will be performed by reacting the Bi compounds bearing a functional spacer group (e.g. carboxylic groups) with the polymers. For example, carbodiimide chemistry is a well-known procedure for coupling OH with COOH groups in a very efficient way, and several literature procedures are known. Purification (e.g. dialysis) of the polymers and nanoprecipitation under sonication conditions to create nano- and micro-particles with defined sizes according to the guidelines WP2 from UWM and UU. The sizes will be varied over two orders of magnitudes in order to explore the influence on relaxivity. Characterisation of the NPs by state of the art techniques (Infrared spectroscopy, SWAXS, TEM, dynamic light scattering, zeta potential, ZF-NQRS, fast field cycling relaxometry).

  • Webpage with open access database

    Design and implementation of a webpage for communicating general information and results, providing open access to data and for facilitating networking activities.

Publications

  • Novel smart MRI contrast agents based on nuclear quadrupole cross relaxation – pre-selection of promising compounds
    Author(s): C. Gösweiner; R. Fischer; M. Schlögl; D. Kruk; A. Petrovic; S. Spirk; H. Scharfetter
    Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, issue ESMRMB Congress, September 2016, Volume 29, Supplement 1, 2016. Page(s) 247–400.  ISSN: 0968-5243
    DOI: 10.5281/zenodo.159270
  • NOVEL POLYSACCHARIDE-BASED NANOPARTICLES AND THEIR POTENTIAL APPILCATION IN biomedical IMAGING
    Author(s): Božič Mojca, Bračič Matej, Doris Tkaučič, Silvo Hribernik, Manja Kurečič, Kargl Rupert, Spirk Stefan, Mohan Tamilselvan, Stana-Kleinschek Karin

Coordinatore

TECHNISCHE UNIVERSITAET GRAZ
Austria

Contributo UE: EUR 1 231 250


RECHBAUERSTRASSE 12
8010 GRAZ
Austria
Activity type: Higher or Secondary Education Establishments

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Partecipanti

UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE
Poland

Contributo UE: EUR 472 500


UL. OCZAPOWSKIEGO 2
10 719 OLSZTYN
Poland
Activity type: Higher or Secondary Education Establishments

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UNIVERZA V MARIBORU
Slovenia

Contributo UE: EUR 584 125


SLOMSKOV TRG 15
2000 MARIBOR
Slovenia
Activity type: Higher or Secondary Education Establishments

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UMEA UNIVERSITET
Sweden

Contributo UE: EUR 83 750


UNIVERSITETOMRADET
90187 UMEA
Sweden
Activity type: Higher or Secondary Education Establishments

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MEDIZINISCHE UNIVERSITAT GRAZ
Austria

Contributo UE: EUR 92 350


AUENBRUGGERPLATZ 2
8036 GRAZ
Austria
Activity type: Higher or Secondary Education Establishments

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