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Development and disease of the renal tract

Development and disease of the renal tract

Objective

The renal tract (kidneys, the ureters, bladder) is a complex organ system crucial for maintaining the body homeostasis. This organ system arises from different precursor pools through a complex program of patterning, differentiation and morphogenesis in embryonic development. Alteration of this program leads to renal tract malformations (RTM) that are incompatible with a healthy life. While some of these RTM can be surgically corrected, others develop into chronic entities that may lead to renal failure; the burden for the patients and for the socio-economic impact for the health systems is immense. Although congenital RTM are amongst the most frequent human birth defects, the different programs that direct normal and pathological development have remained poorly understood.
The RENALTRACT training network aims to address these deficits and provide a better understanding of the programs that underlie RTM and provide solutions to clinical problems. This shall be achieved by using a multidisciplinary team approach with partners working in complementary disciplines (developmental biology, renal physiology, Omics, clinical medicine). RENALTRACT has unique and distinguishing features by uniting studies on components of the urinary tract, by building a bridge between basic and clinician scientists and by combining state of the art methods from a number of complementary fields in a variety of animal models.
RENALTRACT aims to establish a first class multidisciplinary training program for outstanding Early-Stage Researchers (ESRs) to provide a group of young scientists with expert knowledge to envision and embark on novel therapies of renal tract malformations in the future. ESRs will benefit from an excellent working environment with state-of-the-art technologies and supervision by international leaders in the field and an inter-disciplinary approach. This will be complemented by intersectoral exposure and exchange between the RENALTRACT public and private participants.
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Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Address

Rue Michel Ange 3
75794 Paris

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 051 502,40

Participants (8)

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UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 546 575,76

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 273 287,88

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

EU Contribution

€ 249 216,48

UNIVERSITATSKLINIKUM HEIDELBERG

Germany

EU Contribution

€ 373 824,72

OULUN YLIOPISTO

Finland

EU Contribution

€ 269 145,36

MOSAIQUES DIAGNOSTICS GMBH

Germany

EU Contribution

€ 249 216,48

ACQUIFER AG

Germany

DITABIS DIGITAL BIOMEDICAL IMAGING SYSTEMS AG

Germany

EU Contribution

€ 124 608,24

Project information

Grant agreement ID: 642937

Status

Closed project

  • Start date

    1 June 2015

  • End date

    31 May 2019

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 137 377,32

  • EU contribution

    € 3 137 377,32

Coordinated by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France