Cel Under an ERC Advanced Grant, Professor Shakesheff's team have invented a new intracellular delivery system that overcomes a problem in pluripotent stem cell culture as well as being applicable to many other mammalian cell types. The system, called GAG-binding enhanced transduction (GET), enables intracellular delivery of proteins, nucleic acids and particles into cells that resist other non-viral strategies. The work under ERC Advanced Grant funding has allowed exemplification of the delivery of proteins that promote pluripotency or differentiation, delivery and expression of mRNA and high yield delivery of nano and microparticles.This Proof-of-Concept Application will achieve 6 deliverables that together will generate a robust business plan for commercialisation of GET. We begin by performing, via a European marketing company, a comprehensive market analysis to test our view that GET could be used to replace lentiviral transfection, or as an in vivo reprogramming tool or for other challenngng pharmaceutical applications. Next we take account of the market analysis to refine our technical work resulting in a report that provides robust evidence of market required advantages of GET over competitor products. This technical work will include a consideration of manufacturing routes and costs of goods. In parallel with the technical work we will commission an independent freedom-to-operate report. Finally, we will initiate confidential discussions with potential partners and customers via face-to-face meetings in Europe and the US.The final business plan will establish the technical and commercial feasibility of our approaches in one or more of our target markets. We envisage that at the end of the ERC PoC grant we will attract substantial funding to rapidly progress product launches and licenses. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologycells technologiesstem cells Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-PoC-2014 - ERC Proof of Concept Grant Zaproszenie do składania wniosków ERC-2014-PoC Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-POC - Proof of Concept Grant Instytucja przyjmująca THE UNIVERSITY OF NOTTINGHAM Wkład UE netto € 147 489,00 Adres University Park NG7 2RD Nottingham Zjednoczone Królestwo Zobacz na mapie Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 147 489,00 Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko THE UNIVERSITY OF NOTTINGHAM Zjednoczone Królestwo Wkład UE netto € 147 489,00 Adres University Park NG7 2RD Nottingham Zobacz na mapie Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 147 489,00
