Description du projet DEENESFRITPL Des patchs cardiaques intelligents surveillent la régénération in vivo L’infarctus du myocarde provoque l’obstruction d’une des artères coronaires qui alimentent le tissu cardiaque, ce qui entraîne une restriction de l’apport d’oxygène à un segment du cœur. Cela provoque la mort des cardiomyocytes, mais la cicatrisation et la régénération du tissu cardiaque sont limitées. L’ingénierie tissulaire pourrait constituer une alternative thérapeutique prometteuse pour les cardiopathies ischémiques. Il n’existe cependant aucun moyen de contrôler les performances du tissu créé. Financé par le Conseil européen de la recherche, le projet SmartCardiacPatch entend développer des patchs cardiaques implantables intelligents qui intègrent des composants électroniques pour une surveillance en temps réel. Le patch comprendra un échafaudage en 3D de cellules cardiaques et permettra aux médecins de suivre la régénération du cœur en temps réel, et de gérer la maladie. Afficher les objectifs du projet Masquer les objectifs du projet Objectif Ischemic heart disease is a major cause of death in the Western world. There is no sustainable regenerative therapy available at the moment, with cardiac transplantation being the only therapy. However, tissue engineering is envisioned as a true regenerative therapeutic alternative. Despite the incremental improvements no technology is currently available that can provide on-line monitoring and reporting of the engineered tissue performance, and if needed, automatically activate regenerative processes. As one initial step in that direction, we have recently shown on a non-implantable chip-supported level that a sensory system can be integrated with engineered tissues, providing report on cardiac electrical activity. In this proposal, I plan to expand far beyond the state-of-the-art and develop a conceptually new approach to engineer the next generation of smart implantable cardiac patches. These patches will integrate complex electronics with engineered cardiac tissues to enable on-line monitoring and at the same time self-regulation of the tissue function. Since cardiac performance will be recorded over time, physicians could follow heart regeneration in real-time, providing new means for the disease management. To achieve this goal I will first develop new porous, stretchable and biocompatible microelectronics enabling electrical activity recording and stimulation. The electronics will interact with an efficient electroactive controlled release system enabling on-demand release of biomolecules. The system will be integrated with a 3D biomaterial scaffold and cardiac cells to compose the microelectronic cardiac patch (microECP). Development of feedback loop software will ensure efficient regulation of the patch’s function over time. Next, we will elucidate the interplay between the electronics, scaffold and cells, and provide a proof-of-principle for the microECP in vitro. Finally, we will investigate the regenerative potential of the system following infarction. Champ scientifique medical and health sciencesclinical medicinecardiologycardiovascular diseasescardiac arrhythmiamedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologymechanical engineeringmanufacturing engineeringadditive manufacturingmedical and health sciencesclinical medicinetransplantation Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-StG-2014 - ERC Starting Grant Appel à propositions ERC-2014-STG Voir d’autres projets de cet appel Régime de financement ERC-STG - Starting Grant Institution d’accueil TEL AVIV UNIVERSITY Contribution nette de l'UE € 1 499 500,00 Adresse RAMAT AVIV 69978 Tel Aviv Israël Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 499 500,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire TEL AVIV UNIVERSITY Israël Contribution nette de l'UE € 1 499 500,00 Adresse RAMAT AVIV 69978 Tel Aviv Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 499 500,00
