Community Research and Development Information Service - CORDIS

Moving from genome wide association to elucidating causal mechanisms of electrocardiographic traits

From 2015-07-01 to 2017-09-30, closed project

Project details

Total cost:

EUR 196 380,90

EU contribution:

EUR 196 380,90

Coordinated in:

Netherlands

Call for proposal:

H2020-MSCA-IF-2014See other projects for this call

Funding scheme:

MSCA-IF-GF - Global Fellowships

Objective

Deliverables

Deliverables not available

Publications

  • Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality
    Author(s): Ruben N Eppinga, Yanick Hagemeijer, Stephen Burgess, David A Hinds, Kari Stefansson, Daniel F Gudbjartsson, Dirk J van Veldhuisen, Patricia B Munroe, Niek Verweij, Pim van der Harst
    Published in: Nature Genetics, issue 48/12, 2016. Page(s) 1557-1563.  ISSN: 1061-4036
    DOI: 10.1038/ng.3708
  • Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality
    Author(s): M. Abdullah Said, Ruben N. Eppinga, Erik Lipsic, Niek Verweij, Pim van der Harst
    Published in: Journal of the American Heart Association, issue 7/2, 2018. Page(s) e007621.  ISSN: 2047-9980
    DOI: 10.1161/JAHA.117.007621
  • Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
    Author(s): Helen R Warren, Evangelos Evangelou, Claudia P Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P Cook, Aldi T Kraja, Fotios Drenos, Marie Loh, Niek Verweij, Jonathan Marten, Ibrahim Karaman, Marcelo P Segura Lepe, Paul F O'Reilly, Joanne Knight, Harold Snieder, Norihiro Kato, Jiang He, E Shyong Tai, M Abdullah Said, David Porteous, Maris Alver, Neil Poulter, Martin Farrall, Ron T Gansevoort, Sandosh Padmanabhan, Reedik Mägi, Alice Stanton, John Connell, Stephan J L Bakker, Andres Metspalu, Denis C Shields, Simon Thom, Morris Brown, Peter Sever, Tõnu Esko, Caroline Hayward, Pim van der Harst, Danish Saleheen, Rajiv Chowdhury, John C Chambers, Daniel I Chasman, Aravinda Chakravarti, Christopher Newton-Cheh, Cecilia M Lindgren, Daniel Levy, Jaspal S Kooner, Bernard Keavney, Maciej Tomaszewski, Nilesh J Samani, Joanna M M Howson, Martin D Tobin, Patricia B Munroe, Georg B Ehret, Louise V Wain, Louise V Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J van der Most, A Mesut Erzurumluoglu, Paul O'Reilly, Claudia P Cabrera, Helen R Warren, Lynda M Rose, Germaine C Verwoert, Jouke-Jan Hottenga, Rona J Strawbridge, Tonu Esko, Dan E Arking, Shih-Jen Hwang, Xiuqing Guo, Zoltan Kutalik, Stella Trompet, Nick Shrine, Alexander Teumer, Janina S Ried, Joshua C Bis, Albert V Smith, Najaf Amin, Ilja M Nolte, Leo-Pekka Lyytikäinen, Anubha Mahajan, Nicholas J Wareham, Edith Hofer, Peter K Joshi, Kati Kristiansson, Michela Traglia, Aki S Havulinna, Anuj Goel, Mike A Nalls, Siim Sõber, Dragana Vuckovic, Jian'an Luan, Fabiola Del Greco M, Kristin L Ayers, Jaume Marrugat, Daniela Ruggiero, Lorna M Lopez, Teemu Niiranen, Stefan Enroth, Anne U Jackson, Christopher P Nelson, Jennifer E Huffman, Weihua Zhang, Jonathan Marten, Ilaria Gandin, Sarah E Harris, Tatijana Zemonik, Yingchang Lu, Evangelos Evangelou, Nabi Shah, Martin H de Borst, Massimo Mangino, Bram P Prins, Archie Campbell, Ruifang Li-Gao, Ganesh Chauhan, Christopher Oldmeadow, Gonçalo Abecasis, Maryam Abedi, Caterina M Barbieri, Michael R Barnes, Chiara Batini, Tineka Blake, Michael Boehnke, Erwin P Bottinger, Peter S Braund, Morris Brown, Marco Brumat, Harry Campbell, John C Chambers, Massimiliano Cocca, Francis Collins, John Connell, Heather J Cordell, Jeffrey J Damman, Gail Davies, Eco J de Geus, Renée de Mutsert, Joris Deelen, Yusuf Demirkale, Alex S F Doney, Marcus Dörr, Martin Farrall, Teresa Ferreira, Mattias Frånberg, He Gao, Vilmantas Giedraitis, Christian Gieger, Franco Giulianini, Alan J Gow, Anders Hamsten, Tamara B Harris, Albert Hofman, Elizabeth G Holliday, Marjo-Riitta Jarvelin, Åsa Johansson, Andrew D Johnson, Pekka Jousilahti, Antti Jula, Mika Kähönen, Sekar Kathiresan, Kay-Tee Khaw, Ivana Kolcic, Seppo Koskinen, Claudia Langenberg, Marty Larson, Lenore J Launer, Benjamin Lehne, David C M Liewald, Li Lin, Lars Lind, François Mach, Chrysovalanto Mamasoula, Cristina Menni, Borbala Mifsud, Yuri Milaneschi, Anna Morgan, Andrew D Morris, Alanna C Morrison, Peter J Munson, Priyanka Nandakumar, Quang Tri Nguyen, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Elin Org, Sandosh Padmanabhan, Aarno Palotie, Guillaume Paré, Alison Pattie, Brenda W J H Penninx, Neil Poulter, Peter P Pramstaller, Olli T Raitakari, Meixia Ren, Kenneth Rice, Paul M Ridker, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Jerome I Rotter, Igor Rudan, Yasaman Saba, Aude Saint Pierre, Cinzia F Sala, Antti-Pekka Sarin, Reinhold Schmidt, Rodney Scott, Marc A Seelen, Denis C Shields, David Siscovick, Rossella Sorice, Alice Stanton, David J Stott, Johan Sundström, Morris Swertz, Kent D Taylor, Simon Thom, Ioanna Tzoulaki, Christophe Tzourio, André G Uitterlinden, Uwe Völker, Peter Vollenweider, Sarah Wild, Gonneke Willemsen, Alan F Wright, Jie Yao, Sébastien Thériault, David Conen, Attia John, Peter Sever, Stéphanie Debette, Dennis O Mook-Kanamori, Eleftheria Zeggini, Tim D Spector, Pim van der Harst, Colin N A Palmer, Anne-Claire Ve
    Published in: Nature Genetics, issue 49/3, 2017. Page(s) 403-415.  ISSN: 1061-4036
    DOI: 10.1038/ng.3768
  • Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery DiseaseNovelty and Significance
    Author(s): Pim van der Harst, Niek Verweij
    Published in: Circulation Research, issue 122/3, 2018. Page(s) 433-443.  ISSN: 0009-7330
    DOI: 10.1161/CIRCRESAHA.117.312086
  • Discovery of novel heart rate-associated loci using the Exome Chip
    Author(s): Marten E. van den Berg, Helen R. Warren, Claudia P. Cabrera, Niek Verweij, Borbala Mifsud, Jeffrey Haessler, Nathan A. Bihlmeyer, Yi-Ping Fu, Stefan Weiss, Henry J. Lin, Niels Grarup, Ruifang Li-Gao, Giorgio Pistis, Nabi Shah, Jennifer A. Brody, Martina Müller-Nurasyid, Honghuang Lin, Hao Mei, Albert V. Smith, Leo-Pekka Lyytikäinen, Leanne M. Hall, Jessica van Setten, Stella Trompet, Bram P. Prins, Aaron Isaacs, Farid Radmanesh, Jonathan Marten, Aiman Entwistle, Jan A. Kors, Claudia T. Silva, Alvaro Alonso, Joshua C. Bis, Rudolf de Boer, Hugoline G. de Haan, Renée de Mutsert, George Dedoussis, Anna F. Dominiczak, Alex S. F. Doney, Patrick T. Ellinor, Ruben N. Eppinga, Stephan B. Felix, Xiuqing Guo, Yanick Hagemeijer, Torben Hansen, Tamara B. Harris, Susan R. Heckbert, Paul L. Huang, Shih-Jen Hwang, Mika Kähönen, Jørgen K. Kanters, Ivana Kolcic, Lenore J. Launer, Man Li, Jie Yao, Allan Linneberg, Simin Liu, Peter W. Macfarlane, Massimo Mangino, Andrew D. Morris, Antonella Mulas, Alison D. Murray, Christopher P. Nelson, Marco Orrú, Sandosh Padmanabhan, Annette Peters, David J. Porteous, Neil Poulter, Bruce M. Psaty, Lihong Qi, Olli T. Raitakari, Fernando Rivadeneira, Carolina Roselli, Igor Rudan, Naveed Sattar, Peter Sever, Moritz F. Sinner, Elsayed Z. Soliman, Timothy D. Spector, Alice V. Stanton, Kathleen E. Stirrups, Kent D. Taylor, Martin D. Tobin, André Uitterlinden, Ilonca Vaartjes, Arno W. Hoes, Peter van der Meer, Uwe Völker, Melanie Waldenberger, Zhijun Xie, Magdalena Zoledziewska, Andrew Tinker, Ozren Polasek, Jonathan Rosand, Yalda Jamshidi, Cornelia M. van Duijn, Eleftheria Zeggini, J. Wouter Jukema, Folkert W. Asselbergs, Nilesh J. Samani, Terho Lehtimäki, Vilmundur Gudnason, James Wilson, Steven A. Lubitz, Stefan Kääb, Nona Sotoodehnia, Mark J. Caulfield, Colin N. A. Palmer, Serena Sanna, Dennis O. Mook-Kanamori, Panos Deloukas, Oluf Pedersen, Jerome I. Rotter, Marcus Dörr, Chris J. O'Donnell, Caroline Hayward, Dan E. Arking, Charles Kooperberg, Pim van der Harst, Mark Eijgelsheim, Bruno H. Stricker, Patricia B. Munroe
    Published in: Human Molecular Genetics, issue 26/12, 2017. Page(s) 2346-2363.  ISSN: 0964-6906
    DOI: 10.1093/hmg/ddx113
  • Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure
    Author(s): Niek Verweij, Ruben N. Eppinga, Yanick Hagemeijer, Pim van der Harst
    Published in: Scientific Reports, issue 7/1, 2017.  ISSN: 2045-2322
    DOI: 10.1038/s41598-017-03062-8
  • Telomere Length and Risk of Cardiovascular Disease and Cancer
    Author(s): M. Abdullah Said, Ruben N. Eppinga, Yanick Hagemeijer, Niek Verweij, Pim van der Harst
    Published in: Journal of the American College of Cardiology, issue 70/4, 2017. Page(s) 506-507.  ISSN: 0735-1097
    DOI: 10.1016/j.jacc.2017.05.044
  • Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram
    Author(s): Niek Verweij, Irene Mateo Leach, Aaron Isaacs, Dan E. Arking, Joshua C. Bis, Tune H. Pers, Marten E. Van Den Berg, Leo-Pekka Lyytikäinen, Phil Barnett, Xinchen Wang, Elsayed Z. Soliman, Cornelia M. Van Duijn, Mika Kähönen, Dirk J. Van Veldhuisen, Jan A. Kors, Olli T. Raitakari, Claudia T. Silva, Terho Lehtimäki, Hans L. Hillege, Joel N. Hirschhorn, Laurie A. Boyer, Wiek H. Van Gilst, Alvaro Alonso, Nona Sotoodehnia, Mark Eijgelsheim, Rudolf A. De Boer, Paul I. W. De Bakker, Lude Franke, Pim Van Der Harst
    Published in: Human Molecular Genetics, issue 25/10, 2016. Page(s) 2093-2103.  ISSN: 0964-6906
    DOI: 10.1093/hmg/ddw058
  • Refining Thromboembolic Risk in the General Population
    Author(s): Ruben N. Eppinga, Minke H.T. Hartman, Niek Verweij, J. Joep van der Harst, Michiel Rienstra, Pim van der Harst
    Published in: Journal of the American College of Cardiology, issue 70/3, 2017. Page(s) 403-404.  ISSN: 0735-1097
    DOI: 10.1016/j.jacc.2017.05.022
  • Meta-analysis of exome chip variants identifies rare and common variants associated with electrocardiographic left ventricular mass
    Author(s): G. Kosova, N. Verweij, P. van der Harst, C. Newton-Cheh, on behalf of the CHARGE Consortium EX-EKG working group.
    Published in: ASHG congress 2015 Baltimore, MD, 2015. 

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands

EU contribution: EUR 196 380,90


HANZEPLEIN 1
9713 GZ GRONINGEN
Netherlands
Activity type: Higher or Secondary Education Establishments

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Partner organisations

THE GENERAL HOSPITAL CORPORATION
United States
FRUIT STREET 55
02114 BOSTON MA
United States
Activity type: Research Organisations

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