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Focal Adhesion Kinetics In nanosurface Recognition

Project information

Grant agreement ID: 648892

Status

Ongoing project

  • Start date

    1 August 2015

  • End date

    31 July 2020

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 128 895

  • EU contribution

    € 2 128 895

Hosted by:

UNIVERSITY OF GLASGOW

United Kingdom

Objective

The provision of advanced functional materials in the area of regenerative medicine and discovery applications depends on many different factors to provide the appropriate targeted function. As adherent cells also read their environment through substrate interactions there is a great interest in developing such substrates in a predictable manner. Their first point of contact is through their focal adhesions and it is also though them that forces are applied allowing the cell to migrate and establish cytoskeletal tension which in turn regulates cell function. The objective of this project is to investigate the cell-substrate interaction at the nanoscale and correlate that to the surface topography for predictable biomaterials. Through the application of state-of-the-art nanofabrication we will fabricate precise surface topographies with length scales comparable to the structural units found in the focal adhesions. The aim is to map and understand the topographical influence in the architectural arrangement of the proteins in the adhesions. Aided by high resolution microscopy we will classify cell types on different nanotopographies. Combining that information with machine learning, we will be able to gain information about cell characteristics from the rule set. That information can also be used in reverse to identify cell types with the previously defined characteristic. This approach is similar to face recognition seen on cameras and mobile phones.

The proposed research project will not only provide insight to an area of biomaterials not previously explored, yet aim to provide a blueprint for future design of biomaterials.
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Host institution

UNIVERSITY OF GLASGOW

Address

University Avenue
G12 8qq Glasgow

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 128 895

Beneficiaries (1)

UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 2 128 895

Project information

Grant agreement ID: 648892

Status

Ongoing project

  • Start date

    1 August 2015

  • End date

    31 July 2020

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 128 895

  • EU contribution

    € 2 128 895

Hosted by:

UNIVERSITY OF GLASGOW

United Kingdom