Prosaposin and GPR37 in synucleinopathies

Project Information

PROGSY

Grant agreement ID: 649116

DOI 10.3030/649116

Project closed

EC signature date 16 July 2015

Start date 1 August 2015

End date 31 January 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 950 033,00

EU contribution € 1 950 033,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

Publications

Peer reviewed articles (9)

Cytosolic GPR37, but not GPR37L1, multimerization and its reversal by Parkin: A live cellimaging study.

Author(s): Li T, Oasa S, Ciruela F, Terenius L, Vukojević V, Svenningsson P.
Published in: FASEB J., Issue Dec;35(12), 2021, Page(s) e22055, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101213r

α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid fromParkinson's disease patients.

Author(s): Paslawski W, Zareba-Paslawska J, Zhang X, Hölzl K, Wadensten H, Shariatgorji M, Janelidze S, Hansson O, Forsgren L, Andrén PE, Svenningsson P.
Published in: Proc Natl Acad Sci U S A., Issue 116, 2019, Page(s) 15226-15235, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1821409116

Ecto-GPR37: a potential biomarker for Parkinson’s disease

Author(s): Morató, Xavier; Garcia-Esparcia, Paula; Argerich, Josep; Llorens, Franc; Zerr, Inga; Paslawski, Wojciech; Borràs, Eva; Sabidó, Eduard; Petäjä-Repo, Ulla E.; Fernández-Dueñas, Víctor; Ferrer, Isidro; Svenningsson, Per; Ciruela, Francisco
Published in: Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-14 (2021), Issue 3, 2021, ISSN 2047-9158
Publisher: BMC
DOI: 10.1186/s40035-021-00232-7

GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling.

Author(s): Hertz E, Saarinen M, Svenningsson P
Published in: Int J Mol Sci, Issue Nov 27;22(23), 2021, Page(s) 12859, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222312859

Folding Underlies Bidirectional Role of GPR37/Pael-R in Parkinson Disease.

Author(s): Leinartaité Lina, Svenningsson Per
Published in: Trends in Pharmacological Sciences, 2017, ISSN 0165-6147
Publisher: Elsevier BV

Asymmetric dopaminergic degeneration and levodopa alter functional corticostriatal connectivity bilaterally in experimental parkinsonism

Author(s): Cyril Monnot, Xiaoqun Zhang, Sahar Nikkhou-Aski, Peter Damberg, Per Svenningsson
Published in: Experimental Neurology, Issue 292, 2017, Page(s) 11-20, ISSN 0014-4886
Publisher: Academic Press
DOI: 10.1016/j.expneurol.2017.02.014

GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells

Author(s): E. Hertz, L. Terenius, V. Vukojević, P. Svenningsson
Published in: Neuropharmacology, Issue 152, 2019, Page(s) 51-57, ISSN 0028-3908
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2018.11.009

Deficits in motor performance, neurotransmitters and synaptic plasticity in elderly and experimental parkinsonian mice lacking GPR37

Author(s): Zhang X, Mantas I, Fridjonsdottir E, Andrén PE, Chergui K and Svenningsson P
Published in: Frontiers in Aging Neuroscience, Issue 2020.00084, 2020, Page(s) 84-89, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi

The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.

Author(s): Veenit V, Zhang X, Ambrosini A, Sousa V, Svenningsson P
Published in: Int J Mol Sci., Issue Dec 30;23(1), 2021, Page(s) 410, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23010410