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Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases

Objective

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2+ ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling.
The objectives of CaSR Biomedicine are:
1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective.
2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general;
3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders.
4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area.
Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

MEDIZINISCHE UNIVERSITAET WIEN
Address
Spitalgasse 23
1090 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 511 868,16

Participants (12)

CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 273 287,88
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
FUNDACIO SANT JOAN DE DEU
Spain
EU contribution
€ 247 872,96
Address
Calle Santa Rosa, 39-57
08950 Esplugues De Llobregat
Activity type
Research Organisations
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 290 081,88
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 273 287,88
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 273 287,88
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 258 061,32
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 273 287,88
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE PICARDIE JULES VERNE
France
EU contribution
€ 262 875,60
Address
Chemin Du Thil
80025 Amiens
Activity type
Higher or Secondary Education Establishments
STICHTING VU
Netherlands
EU contribution
€ 255 374,28
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
BIOTALENTUM TUDASFEJLESZTO KFT
Hungary
EU contribution
€ 223 913,52
Address
Aulich Lajos Utca 26
2100 Goedoello
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
S.A.F.AN. BIOINFORMATICS - SAS DI PUGLIESE LUISA
Italy
EU contribution
€ 258 061,32
Address
Via Fulvio Croce 23/B
10136 Torino
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TISSUEGNOSTICS GMBH
Austria
EU contribution
€ 255 934,08
Address
Taborstrasse 10/2
1020 Vienna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (5)

FH JOANNEUM GESELLSCHAFT MBH
Austria
Address
Alte Poststrasse 149
8020 Graz
Activity type
Higher or Secondary Education Establishments
AHT-Management
Hungary
Address

Budapest
Activity type
Other
NOVARTIS PHARMA AG
Switzerland
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Amgen GmbH
Austria
Address

Wien
Activity type
Other
IMABIOTECH SAS
France
Address
152 Rue Du Docteur Yersin
59120 Loos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)