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A multidisciplinary approach to cell division: From human oocyte to synthetic biology

A multidisciplinary approach to cell division: From human oocyte to synthetic biology

Objective

The cell is the universal unit of living matter, and there cannot be propagation of life without cell division. DivIDe aims to investigate the mechanisms and principles of cell division and to reproduce them in vitro with synthetic approaches. Crucial to cell division is the mitotic spindle, a structure whose main duty is the separation of chromosomes. The spindle is made of microtubules (MT), molecular motors, and MT-binding factors, some of which show astounding complexity. The mitotic spindle is the one of the cellular structures that best represents the ability of biological matter to self-organize though arrays of dynamic protein-protein interactions. It rapidly assembles when cells enter mitosis, and it disassembles, after sister chromatid separation and mitotic exit. The complexity and dynamic behaviour of the mitotic spindle captures the imagination of synthetic biologists and modellers. These “molecular engineers” try to understand and harness the principles of self-organization to generate new biological structures endowed with the most typical features of biological matter, the ability to harness energy to do mechanical or chemical work. The emerging discipline of synthetic biology aims to bring together modellers, physicists, and chemists, with biochemists, structural biologists and cell biologists. So does DivIDe, which will train a new generation of molecular engineers endowed with a strong basis in quantitative computational and biochemical methods, and therefore capable of addressing cellular and molecular mechanisms. Furthermore, molecular engineering harbours industrial applications, and DivIDe will continuously provide results for potential exploitation by the three SME partners. Training in management skills, conceptual and ethical thinking, communication and networking will complement the scientific offer. In summary, DivIDe will be able to teach an integrated package of skills and will train the molecular biologists of the future.
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Coordinator

FUNDACIO CENTRE DE REGULACIO GENOMICA

Address

Carrer Doctor Aiguader 88
08003 Barcelona

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 495 745,92

Participants (8)

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INSTITUT CURIE

France

EU Contribution

€ 684 936,98

EUVITRO SLU

Spain

EU Contribution

€ 247 872,96

THE FRANCIS CRICK INSTITUTE LIMITED

United Kingdom

EU Contribution

€ 273 287,88

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 249 216,48

LEAD DISCOVERY CENTER GMBH

Germany

EU Contribution

€ 249 216,48

TECHNISCHE UNIVERSITAET DRESDEN

Germany

EU Contribution

€ 249 216,48

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 89 994,84

CHERRY BIOTECH

France

EU Contribution

€ 262 875,60

Partners (3)

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INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH

ELVESYS SAS

Project information

Grant agreement ID: 675737

Status

Ongoing project

  • Start date

    1 April 2016

  • End date

    31 March 2020

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 802 363,62

  • EU contribution

    € 2 802 363,62

Coordinated by:

FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain