Community Research and Development Information Service - CORDIS

COMAL:COhesin Mutations in Acute Leukemia: from modeling and mechanisms to novel therapeutics

From 2015-09-01 to 2020-08-31, ongoing project

Project details

Total cost:

EUR 1 999 574

EU contribution:

EUR 1 999 574

Coordinated in:

United Kingdom

Call for proposal:

ERC-2014-CoGSee other projects for this call

Funding scheme:

ERC-COG - Consolidator Grant

Objective

Deliverables

Deliverables not available

Publications

  • Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
    Author(s): Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S.H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M.L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza, Brian J.P. Huntly
    Published in: Blood, 2018. Page(s) blood-2017-12-820035.  ISSN: 0006-4971
    DOI: 10.1182/blood-2017-12-820035
  • Functional interdependence of BRD4 and DOT1L in MLL leukemia
    Author(s): Omer Gilan, Enid Y N Lam, Isabelle Becher, Dave Lugo, Ester Cannizzaro, Gerard Joberty, Aoife Ward, Meike Wiese, Chun Yew Fong, Sarah Ftouni, Dean Tyler, Kym Stanley, Laura MacPherson, Chen-Fang Weng, Yih-Chih Chan, Margherita Ghisi, David Smil, Christopher Carpenter, Peter Brown, Neil Garton, Marnie E Blewitt, Andrew J Bannister, Tony Kouzarides, Brian J P Huntly, Ricky W Johnstone, Gerard Drewes, Sarah-Jane Dawson, Cheryl H Arrowsmith, Paola Grandi, Rab K Prinjha, Mark A Dawson
    Published in: Nature Structural & Molecular Biology, issue 23/7, 2016. Page(s) 673-681.  ISSN: 1545-9993
    DOI: 10.1038/nsmb.3249
  • A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation
    Author(s): K Kollmann, W Warsch, C Gonzalez-Arias, F L Nice, E Avezov, J Milburn, J Li, D Dimitropoulou, S Biddie, M Wang, E Poynton, M Colzani, M R Tijssen, S Anand, U McDermott, B Huntly, T Green
    Published in: Leukemia, issue 31/4, 2016. Page(s) 934-944.  ISSN: 0887-6924
    DOI: 10.1038/leu.2016.280
  • A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression
    Author(s): George Giotopoulos, Louise van der Weyden, Hikari Osaki, Alistair G. Rust, Paolo Gallipoli, Eshwar Meduri, Sarah J. Horton, Wai-In Chan, Donna Foster, Rab K. Prinjha, John E. Pimanda, Daniel G. Tenen, George S. Vassiliou, Steffen Koschmieder, David J. Adams, Brian J.P. Huntly
    Published in: The Journal of Experimental Medicine, issue 212/10, 2015. Page(s) 1551-1569.  ISSN: 0022-1007
    DOI: 10.1084/jem.20141661
  • Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
    Author(s): Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, Maxine Gia Binh Tran, Vinothini Rajeeve, Simone Cardaci, Sarah Foster, Haiyang Yun, Pedro Cutillas, Anne Warren, Vincent Gnanapragasam, Eyal Gottlieb, Kristian Franze, Brian Huntly, Eamonn Richard Maher, Patrick Henry Maxwell, Julio Saez-Rodriguez, Christian Frezza
    Published in: Nature, issue 537/7621, 2016. Page(s) 544-547.  ISSN: 0028-0836
    DOI: 10.1038/nature19353
  • Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
    Author(s): Christopher A.G. Booth, Nikolaos Barkas, Wen Hao Neo, Hanane Boukarabila, Elizabeth J. Soilleux, George Giotopoulos, Noushin Farnoud, Alice Giustacchini, Neil Ashley, Joana Carrelha, Lauren Jamieson, Deborah Atkinson, Tiphaine Bouriez-Jones, Rab K. Prinjha, Thomas A. Milne, David T. Teachey, Elli Papaemmanuil, Brian J.P. Huntly, Sten Eirik W. Jacobsen, Adam J. Mead
    Published in: Cancer Cell, issue 33/2, 2018. Page(s) 274-291.e8.  ISSN: 1535-6108
    DOI: 10.1016/j.ccell.2018.01.006
  • Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors
    Author(s): Sarah J. Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodson, Penny Wright, Ken G. Smith, Patrick Maxwell, Jude Fitzgibbon, Ming Q. Du, David J. Adams, Brian J. P. Huntly
    Published in: Nature Cell Biology, issue 19/9, 2017. Page(s) 1093-1104.  ISSN: 1465-7392
    DOI: 10.1038/ncb3597
  • A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients
    Author(s): D Beck, J A I Thoms, C Palu, T Herold, A Shah, J Olivier, L Boelen, Y Huang, D Chacon, A Brown, M Babic, C Hahn, M Perugini, X Zhou, B J Huntly, A Schwarzer, J-H Klusmann, W E Berdel, B Wörmann, T Büchner, W Hiddemann, S K Bohlander, L B To, H S Scott, I D Lewis, R J D'Andrea, J W H Wong, J E Pimanda
    Published in: Leukemia, issue 32/2, 2017. Page(s) 263-272.  ISSN: 0887-6924
    DOI: 10.1038/leu.2017.210
  • BET inhibitor resistance emerges from leukaemia stem cells
    Author(s): Chun Yew Fong, Omer Gilan, Enid Y. N. Lam, Alan F. Rubin, Sarah Ftouni, Dean Tyler, Kym Stanley, Devbarna Sinha, Paul Yeh, Jessica Morison, George Giotopoulos, Dave Lugo, Philip Jeffrey, Stanley Chun-Wei Lee, Christopher Carpenter, Richard Gregory, Robert G. Ramsay, Steven W. Lane, Omar Abdel-Wahab, Tony Kouzarides, Ricky W. Johnstone, Sarah-Jane Dawson, Brian J. P. Huntly, Rab K. Prinjha, Anthony T. Papenfuss, Mark A. Dawson
    Published in: Nature, issue 525/7570, 2015. Page(s) 538-542.  ISSN: 0028-0836
    DOI: 10.1038/nature14888
  • A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
    Author(s): Konstantinos Tzelepis, Hiroko Koike-Yusa, Etienne De Braekeleer, Yilong Li, Emmanouil Metzakopian, Oliver M. Dovey, Annalisa Mupo, Vera Grinkevich, Meng Li, Milena Mazan, Malgorzata Gozdecka, Shuhei Ohnishi, Jonathan Cooper, Miten Patel, Thomas McKerrell, Bin Chen, Ana Filipa Domingues, Paolo Gallipoli, Sarah Teichmann, Hannes Ponstingl, Ultan McDermott, Julio Saez-Rodriguez, Brian J.P. Huntly, Francesco Iorio, Cristina Pina, George S. Vassiliou, Kosuke Yusa
    Published in: Cell Reports, issue 17/4, 2016. Page(s) 1193-1205.  ISSN: 2211-1247
    DOI: 10.1016/j.celrep.2016.09.079
  • Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia
    Author(s): Louise van der Weyden, George Giotopoulos, Kim Wong, Alistair G. Rust, Carla Daniela Robles-Espinoza, Hikari Osaki, Brian J. Huntly, David J. Adams
    Published in: BMC Cancer, issue 15/1, 2015.  ISSN: 1471-2407
    DOI: 10.1186/s12885-015-1586-1
  • Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development
    Author(s): Neil A. Barrett, Camille Malouf, Chrysa Kapeni, Wendi A. Bacon, George Giotopoulos, Sten Eirik W. Jacobsen, Brian J. Huntly, Katrin Ottersbach
    Published in: Cell Reports, issue 16/4, 2016. Page(s) 1039-1054.  ISSN: 2211-1247
    DOI: 10.1016/j.celrep.2016.06.046
  • Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies
    Author(s): Thomas McKerrell, Thaidy Moreno, Hannes Ponstingl, Niccolo Bolli, João M. L. Dias, German Tischler, Vincenza Colonna, Bridget Manasse, Anthony Bench, David Bloxham, Bram Herman, Danielle Fletcher, Naomi Park, Michael A. Quail, Nicla Manes, Clare Hodkinson, Joanna Baxter, Jorge Sierra, Theodora Foukaneli, Alan J. Warren, Jianxiang Chi, Paul Costeas, Roland Rad, Brian Huntly, Carolyn Grove, Zemin Ning, Chris Tyler-Smith, Ignacio Varela, Mike Scott, Josep Nomdedeu, Ville Mustonen, George S. Vassiliou
    Published in: Blood, issue 128/1, 2016. Page(s) e1-e9.  ISSN: 0006-4971
    DOI: 10.1182/blood-2015-11-683334

Host Institution

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

EU contribution: EUR 1 999 574


TRINITY LANE THE OLD SCHOOLS
CB2 1TN CAMBRIDGE
United Kingdom
Activity type: Higher or Secondary Education Establishments

Contact the organisation

Beneficiaries

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

EU contribution: EUR 1 999 574


TRINITY LANE THE OLD SCHOOLS
CB2 1TN CAMBRIDGE
United Kingdom
Activity type: Higher or Secondary Education Establishments

Contact the organisation

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