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Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Objective

Tendon Therapy Train is a research, training and innovation programme for human and equine tendon repair and regeneration that will exploit recent advancements in tissue engineering by self-assembly (TESA) technologies which have led to the clinical translation and commercialisation of advanced therapy medicinal products (ATMPs). Although TESA therapies have the potential to revolutionise healthcare for numerous clinical targets, a lack of researchers with the necessary interdisciplinary skillset to advance the field is limiting clinical translation. Tendon therapy train, a network of 8 beneficiaries and 8 partners (7 universities, 7 companies and 2 hospitals) from six countries across Europe, will train a cohort of 15 researchers to doctoral level in the interdisciplinary area of ATMPs. The innovative credentials of the research and training programme involve engineering suitable ex vivo culture environments that, by mimicking the native tendon tissue milieu (human and equine), will maintain the tenogenic phenotype of tendon derived cells and differentiate non-tendon derived cells (stem cells and dermal fibroblasts) towards the tenogenic lineage, subsequently enabling development of three-dimensional cell-assembled tissue equivalents, the clinical potential of which will be assessed in suitable preclinical models. The comprehensive Tendon Therapy Train programme will equip researchers with transferable inter- and multidisciplinary skills that will further European-based knowledge, innovation, competitiveness and leadership in the field of TESA / ATMP and ultimately enable clinical translation and commercialisation of the developed technologies.

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY

Address

University Road
H91 Galway

Ireland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 062 698,40

Participants (8)

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UNIVERSIDADE DO MINHO

Portugal

EU Contribution

€ 238 356,36

THE ROYAL VETERINARY COLLEGE

United Kingdom

EU Contribution

€ 546 575,76

UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 510 748,56

SOFRADIM PRODUCTION SASU

France

EU Contribution

€ 262 875,60

TECHNOLOGIKO EKPEDEFTIKO IDRYMA IPIROU

Greece

EU Contribution

€ 727 160,76

STEMCELL TECHNOLOGIES SARL

France

PROXY BIOMEDICAL LIMITED

Ireland

EU Contribution

€ 265 674,60

STEMCELL TECHNOLOGIES UK LTD

United Kingdom

EU Contribution

€ 262 875,60

Partners (7)

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Galway Clinic

Aristotle University

PANEPISTIMIO THESSALIAS

Bose

NAMSA

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Cell Scale

Project information

Grant agreement ID: 676338

Status

Ongoing project

  • Start date

    1 February 2016

  • End date

    31 January 2020

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 876 965,65

  • EU contribution

    € 3 876 965,64

Coordinated by:

NATIONAL UNIVERSITY OF IRELAND GALWAY

Ireland