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Multi-Scale Complex Genomics

Objective

Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part of the regulation of gene expression is implicitly coded in the way in which chromatin is folded. As technology has advanced and information of the folded state of chromatin has emerged, a new branch of genomics (3D/4D genomics) has emerged. Hundreds of laboratories are now defining a young and active community that, though in the end concerned with the same scientific problem, uses many different approaches to study it that individually target radically different length and timescales. The community faces severe practical problems related to: i) how huge, noisy, and diverse data related to widely different size and time scales can be integrated, ii) the lack of standardized analysis and simulation tools, iii) the complete disconnection of associated informatics databases, and iv) the lack of validated and flexible visualization engines. MuG is born at the critical point in the evolution of the field, in a bottom-up approach from the biologist who are suffering severe IT problemes. MuG, supported by European leaders in the field, join three different expertise: biologist with interest in chromatin structure, methods developers and HPC facilities with strong history of supporting Bio-computational problems. We believe that MuG will be a steep-forward in approaching the potential of High Performance Computing to the development of 3D/4D genomics, and will contribute to give a structure to this new and exciting field.

Call for proposal

H2020-EINFRA-2015-1
See other projects for this call

Coordinator

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Address
Carrer Baldiri Reixac 10-12 Parc Scientific De Barcelona
08028 Barcelona
Spain
Activity type
Research Organisations
EU contribution
€ 668 625

Participants (5)

BARCELONA SUPERCOMPUTING CENTER-CENTRO NACIONAL DE SUPERCOMPUTACION
Spain
EU contribution
€ 470 250
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Research Organisations
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 510 695
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 408 091
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 335 547
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 567 955
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations