Project description DEENESFRITPL Uncovering the epigenetics of memory functions Neuroepigenetics is an emerging field that investigates epigenetic-linked processes in the context of neuronal plasticity, memory function, and brain disease. The ERC-funded DEPICODE project aims to consolidate the field of neuroepigenetics and uncover details of the mechanisms by which epigenetic processes affect memory formation under physiological and pathological conditions. The objective is to investigate how the epigenetic code is translated into cellular changes that mediate memory formation and how epigenetic mechanisms contribute to the transmission of cognitive phenotypes across generations. The results of the study will provide an understanding of the mechanisms that underlie memory formation and pave the way for the development of new therapies for age-related cognitive disorders. Show the project objective Hide the project objective Objective The emerging field of neuroepigenetics investigates processes such as histone-acetylation in the context ofneuronal plasticity, memory function and brain diseases. My group has significantly contributed to this novelresearch field. It is however fair to say that the role of “epigenetics” in memory function is still met withsome skepticism in the neurosciences, which is in part due to the fact that many of the current studies havebeen describing phenomena and mechanistic data to explain how epigenetic processes control memoryfunction in health and disease are comparatively sparse. The major objective of this research proposal is toaddress this issue and help to consolidate the field of neuroepigenetics by providing insight to themechanisms by which epigenetic processes contribute to memory formation under physiological andpathological conditions. More specifically I will ask how the epigenetic code is translated into cellularchanges that mediate memory formation in health and disease and how can epigenetic mechanismscontribute to the transmission of cognitive phenotypes even across generations. Our results will not onlyprovide import insight to the mechanisms that underlie memory formation but will also lay the basis for thedevelopment of novel and improved therapies for age-related cognitive disorders. Fields of science natural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesclinical medicinepsychiatryschizophrenianatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesnatural sciencesbiological sciencesgeneticsepigenetics Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-CoG-2014 - ERC Consolidator Grant Call for proposal ERC-2014-CoG See other projects for this call Funding Scheme ERC-COG - Consolidator Grant Coordinator DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV Net EU contribution € 1 729 125,00 Address Venusberg-campus 1/99 53127 Bonn Germany See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 729 125,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV Germany Net EU contribution € 1 729 125,00 Address Venusberg-campus 1/99 53127 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 729 125,00