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Probing safety of nano-objects by defining immune responses of environmental organisms

Objective

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g., iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species.
PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing.
PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.

Call for proposal

H2020-MSCA-ITN-2015
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Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 516 122,64

Participants (10)

PARIS-LODRON-UNIVERSITAT SALZBURG
Austria
EU contribution
€ 255 934,08
Address
Kapitelgasse 4-6
5020 Salzburg
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI GENOVA
Italy
EU contribution
€ 258 061,32
Address
Via Balbi 5
16126 Genova
Activity type
Higher or Secondary Education Establishments
MIKROBIOLOGICKY USTAV AV CR V.V.I
Czechia
EU contribution
€ 232 422,48
Address
Videnska 1083
142 00 Praha 4
Activity type
Research Organisations
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 249 216,48
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 234 997,56
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 273 287,88
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
UNITED KINGDOM RESEARCH AND INNOVATION

Participation ended

United Kingdom
EU contribution
€ 113 869,95
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
AvantiCell Science Ltd
United Kingdom
EU contribution
€ 273 287,88
Address
Gibbsyard Building
KA6 5HW Ayr
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spain
EU contribution
€ 247 872,96
Address
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)
Activity type
Research Organisations
UK CENTRE FOR ECOLOGY & HYDROLOGY
United Kingdom
EU contribution
€ 159 417,93
Address
Maclean Building Benson Lane
OX10 8BB Oxford
Activity type
Research Organisations

Partners (1)

ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
Address
Via Fiorentina 151
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)