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Probing safety of nano-objects by defining immune responses of environmental organisms

Objective

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g., iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species.
PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing.
PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Research Organisations

EU Contribution

€ 516 122,64

Participants (10)

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PARIS-LODRON-UNIVERSITAT SALZBURG

Austria

EU Contribution

€ 255 934,08

UNIVERSITA DEGLI STUDI DI GENOVA

Italy

EU Contribution

€ 258 061,32

MIKROBIOLOGICKY USTAV AV CR V.V.I

Czechia

EU Contribution

€ 232 422,48

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

EU Contribution

€ 249 216,48

UNIVERZA V LJUBLJANI

Slovenia

EU Contribution

€ 234 997,56

CARDIFF UNIVERSITY

United Kingdom

EU Contribution

€ 273 287,88

UNITED KINGDOM RESEARCH AND INNOVATION

United Kingdom

EU Contribution

€ 273 287,88

NATURAL ENVIRONMENT RESEARCH COUNCIL

United Kingdom

AvantiCell Science Ltd

United Kingdom

EU Contribution

€ 273 287,88

FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA

Spain

EU Contribution

€ 247 872,96

Partners (1)

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ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU

Project information

Grant agreement ID: 671881

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 December 2019

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 814 491,16

  • EU contribution

    € 2 814 491,16

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy