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In the eye of the observer: Visual processing at the heart of the retina

Project information

Grant agreement ID: 674901

Status

Closed project

  • Start date

    1 November 2015

  • End date

    31 October 2019

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 867 784,98

  • EU contribution

    € 3 867 784,92

Coordinated by:

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

Objective

All visual information is broadcasted by an intra-retinal pathway formed by a group of neurons called bipolar cells. They collect photoreceptor signals in the outer retina and relay the signals to the inner retinal neurons. This transfer of visual information is far from passive: Each of the at least 10 bipolar cell types transforms the photoreceptor signals in a unique and highly specific way. As a result, the bipolar cell output signals form the first “elementary operations” from which the neural circuits of the inner retina compose a feature-oriented description of the visual world. Reflecting the partitioning of visual information into parallel channels, the retinal layer in which bipolar cell axon terminals meet their synaptic partners, is highly organized: This so-called “inner plexiform layer” effectively serves as the retina’s “switch board”: The input is provided by the different bipolar cell “channels”, while the output is carried by an even larger number of channels, represented by ganglion cells that form the optic nerve. Each of the ~20 ganglion cell types composes its feature-extracting circuits from a specific set of bipolar cell input it receives. Owing to its regular structure and ease of experimental access, the retina is amongst the best understood self-standing neuronal networks in neuroscience. Indeed, recent advances hold the exciting promise that an in-depth understanding of the bipolar cells – an entire class of neurons – and their role in the first critical steps of visual processing is within reach. Our proposal aims to train young researchers in world-leading research labs towards completing this goal. We will accomplish this by exposing the students to a host of cutting-edge techniques and a broad spectrum of research approaches within the training network – from imaging at synaptic resolution, transgenetics and retina degeneration models to the application of retinal circuit principles for signal processing in artificial vision chips.
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Coordinator

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Address

Geschwister-Scholl-Platz
72074 Tuebingen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 498 432,90

Participants (10)

CARL VON OSSIETZKY UNIVERSITAET OLDENBURG

Germany

EU Contribution

€ 249 216,48

UNIVERSITETET I BERGEN

Norway

EU Contribution

€ 286 275,24

THE UNIVERSITY OF SUSSEX

United Kingdom

EU Contribution

€ 522 504,42

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Netherlands

EU Contribution

€ 510 748,56

TECHNISCHE UNIVERSITAET WIEN

Austria

EU Contribution

€ 255 934,08

UNIVERSITAET INNSBRUCK

Austria

EU Contribution

€ 511 868,16

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 258 061,32

MULTI CHANNEL SYSTEMS MCS GMBH

Germany

EU Contribution

€ 249 216,48

EKB TECHNOLOGIES LTD

Israel

EU Contribution

€ 260 300,52

INILABS AG

Switzerland

EU Contribution

€ 265 226,76

Partners (4)

NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN

Germany

European Vision Institute

Belgium

Vilvite-The Bergen Science Center

Norway

Grasshopper Films GmbH

Germany

Project information

Grant agreement ID: 674901

Status

Closed project

  • Start date

    1 November 2015

  • End date

    31 October 2019

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 867 784,98

  • EU contribution

    € 3 867 784,92

Coordinated by:

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany