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Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity

Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity

Objective

The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell polarity requires knowledge of the molecular players involved and a quantitative description of their biochemical interactions, as well as the mechanical processes underlying polarity establishment. PolarNet brings together academic and private partners from 7 European countries to establish a multidisciplinary, intersectoral training and research programme that will study the basic principles of cell polarity. The research will combine complementary model systems ranging from fungi and cultured mammalian cells to whole organisms, and employ a broad set of approaches such as advanced genetics, protein biochemistry, high-resolution live imaging and image analysis, biophysics and theoretical modelling. This setting provides an opportunity to train early stage researchers in a unique combination of experimental and theoretical approaches. This will provide an excellent starting point for a successful career in the rapidly expanding field of multidisciplinary or ‘integrative’ biology. Training Europe’s next generation of scientists at the forefront of cell and organismal polarity research is crucial for progress in several medically important fields, including cancer research and stem cell biology. The tight collaboration with non-academic partners will strengthen the technological base of different projects and provide early stage researchers with insights into the translation potential of the performed studies and the career development opportunities in biomedical industry.
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Coordinator

UNIVERSITEIT UTRECHT

Address

Heidelberglaan 8
3584 Cs Utrecht

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 276 871,40

Participants (8)

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TECHNISCHE UNIVERSITAET DRESDEN

Germany

EU Contribution

€ 249 216,48

INSTITUT CURIE

France

EU Contribution

€ 262 875,60

THE FRANCIS CRICK INSTITUTE LIMITED

United Kingdom

EU Contribution

€ 273 287,88

CARDIFF UNIVERSITY

United Kingdom

EU Contribution

€ 546 575,76

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 273 287,88

INSTITUT PASTEUR

France

EU Contribution

€ 525 751,20

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 262 875,60

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 265 226,76

Partners (4)

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ELEVATE BV

NDS Ltd.

Union Biometrica BVBA

Scientific Volume Imaging BV

Project information

Grant agreement ID: 675407

Status

Ongoing project

  • Start date

    1 October 2015

  • End date

    30 September 2019

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 935 968,56

  • EU contribution

    € 3 935 968,56

Coordinated by:

UNIVERSITEIT UTRECHT

Netherlands