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A training network for the rational design of the next generation of well-defined glycoconjugate vaccines

Objective

GLYCOVAX is a network for the education of promising young scientists who will learn how to rationally design a next generation of well-defined and innovative glycoconjugate vaccines to improve current preventive therapies and to tackle unmet medical needs. Glycoconjugate vaccines represent the key for success of vaccination in children. The covalent linkage to proteins renders carbohydrates able to evoke a T-cell memory response. Current vaccines are prepared from heterogeneous mixtures of sugars linked by unspecific methods to the carrier protein giving complex mixtures of products. Due to this intricate structure, it has not been possible to apply a medicinal chemistry approach in the development of glycoconjugate vaccines and to fully understand their mechanism of action. Combination of novel approaches for glycan synthesis and site-selective conjugation methods now gives access to conjugates defined in sugar component and attachment site, thus leading to robust structure-immunogenicity relationship. Advancements in structural biophysics can be applied to select the optimal glycan antigen. By combining the beneficiaries’ expertise in carbohydrate synthesis, bioconjugation, high throughput screening, structural glycobiology, vaccinology and immunology, together with the experience in project management, GLYCOVAX will create a multidisciplinary environment where 14 young researchers will contribute to develop a novel route towards improved, safer and better characterized glycoconjugate vaccines, and contemporarily acquire transferable skills which will lead them to become the new leaders of academic or industrial research. The network will involve 9 academic groups and 2 industrial partners as Beneficiaries, and one SME as Partner Organization. The profound interaction between academy and industry will aid the students to get new concepts and visions for translating their ideas from the bench to the manufacturing of the next generation of glycoconjugate vaccines.

Field of science

  • /medical and health sciences/basic medicine/medicinal chemistry
  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /natural sciences/biological sciences/biophysics
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

GLAXOSMITHKLINE VACCINES SRL
Address
Via Fiorentina 1
53100 Siena
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 516 122,64

Participants (10)

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal
EU contribution
€ 238 356,36
Address
Avenida Prof Egas Moniz
1649 028 Lisboa
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 716 837
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 510 748,56
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain
EU contribution
€ 247 872,96
Address
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 262 875,60
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 280 879,21
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
SVEUCILISTE U RIJECI, MEDICINSKI FAKULTET
Croatia
EU contribution
€ 247 761
Address
Brace Branchetta 20
51000 Rijeka
Activity type
Higher or Secondary Education Establishments
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 249 216,48
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Participation ended

Germany
EU contribution
€ 34 613,40
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
GLYCOUNIVERSE GMBH & CO. KOMMANDITGESELLSCHAFT AUF AKTIEN
Germany
EU contribution
€ 249 216,48
Address
Am Muhlenberg 11
14476 Potsdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (1)

ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
Address
Via Fiorentina 151
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)