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FRAGments training NETwork

Objective

The promise of more efficient lead discovery is fuelling the enthusiasm for fragment-based lead discovery (FBLD). In this approach, highly sensitive biochemical and biophysical screening technologies are being used to detect the low affinity binding of low molecular weight compounds (the so-called fragments) to protein targets that are involved in pathophysiological processes. By investigating the molecular interactions between fragment hit(s) and the target protein, a detailed understanding of the binding event is obtained. This enables the rational and efficient optimisation of the hit fragment. The optimised compounds represent high quality leads for drug development. The necessary FBLD technologies and approaches have emerged mainly from small and specialised biotech companies. At present, FBLD is being adopted throughout pharmaceutical sciences, including by pharmaceutical companies, SMEs and academic research groups. So far, the necessary training that is needed to obtain an holistic view of the possibilities and opportunities that FBLD provides is missing, most likely because the highly multidisciplinary nature of the FBLD work is difficult to capture within one (academic) institute. Therefore, we have established FragNet as a dedicated FBLD training network. The consortium consists of the most prominent pharmaceutical companies, biotech companies and academic groups that have jointly shaped the FBLD research area. FragNet is committed to train 15 ESRs in all facets of FBLD using the combined technologies, skills and knowledge. This will include both research (e.g., technologies on the interface of chemistry and biology) and transferable skill sets (e.g., writing, media training, entrepreneurship and thorough understanding of scientific knowledge transfer). This will enable the ESRs to excel in today’s drug discovery and chemical biology programmes that are performed in public and private organisations in the pharmaceutical sciences.

Field of science

  • /social sciences/economics and business/business and management/entrepreneurship

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 021 497,12

Participants (7)

UNIVERSITY OF YORK
United Kingdom
EU contribution
€ 819 863,64
Address
Heslington
YO10 5DD York North Yorkshire
Activity type
Higher or Secondary Education Establishments
TERMESZETTUDOMANYI KUTATOKOZPONT
Hungary
EU contribution
€ 447 827,04
Address
Magyar Tudosok Korutja 2
1117 Budapest
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT DE BARCELONA
Spain
EU contribution
€ 495 745,92
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Activity type
Higher or Secondary Education Establishments
VERNALIS (R&D) LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
Granta Park Great Abington
CB21 6GB Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ZOBIO BV
Netherlands
EU contribution
€ 255 374,28
Address
J.h. Oortweg 19
2333 CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BEACTICA THERAPEUTICS AB
Sweden
EU contribution
€ 263 659,32
Address
Virdings Alle 2
754 50 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 265 226,76
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (5)

GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
F. HOFFMANN-LA ROCHE AG
Switzerland
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DE RECHERCHES SERVIER
France
Address
3 Rue De La Republique
92150 Suresnes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IOTA Pharmaceuticals Ltd
United Kingdom
Address
Cowley Road St Johns Innovation Centre
CB4 0WS Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
24 Media Labs
Netherlands
Address
Vasteland 78
3011 BN Rotterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)