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An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century

Objective

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment.

Call for proposal

H2020-PHC-2015-single-stage_RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITEIT LEIDEN
Address
Rapenburg 70
2311 EZ Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 4 897 069,50

Participants (42)

UNIVERSITAT KONSTANZ
Germany
EU contribution
€ 1 408 187,50
Address
Universitatsstrasse 10
78464 Konstanz
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 1 282 235
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
BASF SE
Germany
EU contribution
€ 695 410
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNILEVER U.K. CENTRAL RESOURCES LIMITED
United Kingdom
EU contribution
€ 21 000
Address
Unilever House, Victoria Embankment 100
EC4Y 0DY London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KAROLINSKA INSTITUTET

Participation ended

Sweden
EU contribution
€ 567 605
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
France
EU contribution
€ 705 015
Address
Parc Technologique Alata
60550 Verneuil En Halatte
Activity type
Research Organisations
COSMETICS EUROPE - THE PERSONAL CARE ASSOCIATION
Belgium
EU contribution
€ 0
Address
Avenue Herrmann Debroux 40
1160 Brussels
Activity type
Other
BIOTALENTUM TUDASFEJLESZTO KFT
Hungary
EU contribution
€ 744 476
Address
Aulich Lajos Utca 26
2100 Goedoello
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BioDetection Systems B.V.
Netherlands
EU contribution
€ 960 218,75
Address
Science Park 406
1098 XH Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 790 690
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Netherlands
EU contribution
€ 626 345
Address
Anna Van Buerenplein 1
2595 DA Den Haag
Activity type
Research Organisations
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 1 057 335
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E.V.
Germany
EU contribution
€ 930 375
Address
Ardeystrasse 67
44139 Dortmund
Activity type
Higher or Secondary Education Establishments
ARTTIC
France
EU contribution
€ 1 395 580
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EDELWEISS CONNECT GMBH
Switzerland
EU contribution
€ 0
Address
Hochbergerstrasse 60C
4057 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 930 065
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
CERTARA UK LIMITED
United Kingdom
EU contribution
€ 690 765
Address
One London Wall 6Th Floor
EC2Y 5EB London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDIZINISCHE UNIVERSITAT INNSBRUCK

Participation ended

Austria
EU contribution
€ 256 237
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 773 260
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD POMPEU FABRA
Spain
EU contribution
€ 723 190
Address
Placa De La Merce, 10-12
08002 Barcelona
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 850 005
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
UNIVERSITAT WIEN
Austria
EU contribution
€ 594 061,05
Address
Universitatsring 1
1010 Wien
Activity type
Higher or Secondary Education Establishments
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
Spain
EU contribution
€ 641 940
Address
Av Fernando Abril Martorell 106
46026 Valencia
Activity type
Research Organisations
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 767 500
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
F. HOFFMANN-LA ROCHE AG
Switzerland
EU contribution
€ 0
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CYPROTEX DISCOVERY LIMITED
United Kingdom
EU contribution
€ 892 455
Address
114 Innovation Drive Milton Park
OX14 4RZ Abingdon Oxfordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TISSUSE GMBH
Germany
EU contribution
€ 695 065
Address
Oudenarder Strasse 16
13347 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JOHNS HOPKINS UNIVERSITY
United States
EU contribution
€ 515 762,50
Address
North Charles Street 3400
21218 Baltimore
Activity type
Higher or Secondary Education Establishments
INSPHERO AG
Switzerland
EU contribution
€ 0
Address
Wagistrasse 27
8952 Schlieren
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 457 718,75
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
STEINBEIS GMBH & CO KG FUR TECHNOLOGIE TRANSFER
Germany
EU contribution
€ 804 130
Address
Adornostrasse 8
70599 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
The Danish Environmental Protection Agency

Participation ended

Denmark
EU contribution
€ 67 507,96
Address
Strandgade 29
1401 Copenhagen
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
L'OREAL SA
France
EU contribution
€ 14 440
Address
14 Rue Royale
75008 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BUNDESANSTALT FUER ARBEITSSCHUTZ UND ARBEITSMEDIZIN
Germany
EU contribution
€ 53 250
Address
Friedrich Henkel Weg 1-25
44149 Dortmund
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 64 000
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom
EU contribution
€ 43 775
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
OPEN PHACTS FOUNDATION LBG
United Kingdom
EU contribution
€ 11 000
Address
Milton Road 290 292 Science Park Thomas Graham House
CB4 0WF Cambridge
Activity type
Research Organisations
LHASA LIMITED
United Kingdom
EU contribution
€ 325 000
Address
Granary Wharf House, 2 Canal Wharf
LS11 5PS Leeds
Activity type
Research Organisations
STICHTING VU
Netherlands
EU contribution
€ 720 387,95
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 97 037,04
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
RISE RESEARCH INSTITUTES OF SWEDEN AB
Sweden
EU contribution
€ 679 381,25
Address
Brinellgatan 4
501 15 Boras
Activity type
Research Organisations
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 48 823,75
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments