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REgenerative Stem cell therapy for STroke in Europe

Objective

Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families.
Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke recovery and patients quality of life. RESSTORE European multicentre randomised phase IIb will explore, for the first time, the efficacy (functional recovery) and safety of intravenous infusion of allogenic adipose tissue derived mesenchymal stem cells (ADMSCs) in 400 stroke patients. Therapeutic effects of ADMSCs will be assessed and monitored in patients using clinical rating scales, multimodal MRI and novel blood biomarkers. Additionally, the societal value and cost-effectiveness of ADMSCs-based regenerative therapy will be evaluated through health economics and predictive in silico simulations. Complementary ancillary animal studies will support the clinical trial by defining i) if the treatment response can be further enhanced by intensive rehabilitation, ii) the contribution of co-morbidities and iii) the mechanism(s) underlying the therapeutic effect.
The European regenerative therapy capacities (France, Spain, Finland, United Kingdom and Czech Republic), developed in RESSTORE will cover the full value chain in the field (large scale GMP cell production, clinical testing, biomarkers discovery, understanding of the restoring mechanisms, modelling, biobanking, economic studies, exploitation and communication plan). RESSTORE will thus surely contribute, together with the workforce trained in the context of the programme, to improve its public and private (SME) competitiveness and increase the attractiveness of Europe as a reference location to develop and clinically assess new innovative therapeutic options for brain diseases.

Field of science

  • /medical and health sciences/basic medicine/physiology/pathophysiology
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /social sciences/economics and business/economics/health economics
  • /medical and health sciences/basic medicine/neurology/stroke
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/computer and information sciences/software/software development
  • /medical and health sciences/clinical medicine/physiotherapy
  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /social sciences/political science/government systems
  • /medical and health sciences/basic medicine/immunology

Call for proposal

H2020-PHC-2015-single-stage_RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITE GRENOBLE ALPES
Address
621 Avenue Centrale
38058 Grenoble
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 781 937,50

Participants (28)

SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 134 600
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE
France
EU contribution
€ 182 700
Address
Boulevard De La Chantourne
38700 La Tronche
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Czechia
EU contribution
€ 20 000
Address
Pekarska 53
656 91 Brno
Activity type
Higher or Secondary Education Establishments
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 446 825
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 20 000
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 185 035
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
ETABLISSEMENT FRANCAIS DU SANG
France
EU contribution
€ 799 718
Address
Avenue Du Stade De France 20
93210 La Plaine Saint Denis
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
TAMPEREEN KORKEAKOULUSAATIO SR
Finland
EU contribution
€ 360 791
Address
Kalevantie 4
33100 Tampere
Activity type
Higher or Secondary Education Establishments
HISTOCELL SL
Spain
EU contribution
€ 327 365
Address
Parque Tecnologico De Bizkaia Edificio 801 Piso 2
48160 Derio Bizkaia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OY MEDFILES LTD
Finland
EU contribution
€ 802 187,50
Address
Volttikatu 5
70700 Kuopio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 130 325
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 350 000
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations
HOSPICES CIVILS DE LYON
France
EU contribution
€ 70 000
Address
Quai Des Celestins 3
69002 Lyon
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
ASSOCIATION GROUPE ESSEC
France
EU contribution
€ 200 000
Address
Avenue Bernard Hirsch
95021 Cergy Pontoise Cedex
Activity type
Higher or Secondary Education Establishments
NOVADISCOVERY
France
EU contribution
€ 274 375
Address
1 Place Giovanni Da Verrazzano
69009 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FINOVATIS
France
EU contribution
€ 232 000
Address
Cours Lafayette 68
69003 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON
France
EU contribution
€ 1 700
Address
Place Saint Jacques 2
25030 Besancon Cedex
Activity type
Research Organisations
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 1 700
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
France
EU contribution
€ 1 700
Address
Rue Viguerie 2 Hotel Dieu Saint Jacques
31052 Toulouse Cedex 3
Activity type
Higher or Secondary Education Establishments
CHU HOPITAUX DE BORDEAUX
France
EU contribution
€ 1 700
Address
Rue Dubernat 12
33404 Talence
Activity type
Higher or Secondary Education Establishments
CHU COTE DE NACRE - CAEN
France
EU contribution
€ 1 700
Address
Avenue De La Cote De Nacre
14033 Caen Cedex 5
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
FUNDACION INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEON
Spain
EU contribution
€ 1 700
Address
Parque Santa Clara
42002 Soria
Activity type
Research Organisations
FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU
Spain
EU contribution
€ 1 700
Address
Calle Sant Antoni M Claret 167
08025 Barcelona
Activity type
Research Organisations
SERVICIO DE SALUD DE CASTILLA LA MANCHA
Spain
EU contribution
€ 1 700
Address
Avenida Rio Guadiana 4
45007 Toledo
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SERVIZO GALEGO DE SAUDE
Spain
EU contribution
€ 1 700
Address
Edificio Administrativo San Lázaro
15703 Santiago De Compostela
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE GIRONA DOCTOR JOSEP TRUETA
Spain
EU contribution
€ 1 700
Address
Calle Dr. Castany Sn Edificio De La Mancomunidad 2 Parque Hospitalario Marti Julia
17190 Girona
Activity type
Research Organisations
PIRKANMAA HOSPITAL DISTRICT
Finland
EU contribution
€ 1 700
Address
Teiskontie 35
33521 Tampere
Activity type
Research Organisations
GROUPE HOSPITALIER UNIVERSITAIRE PARIS PSYCHIATRIE ET NEUROSCIENCES
France
EU contribution
€ 1 700
Address
Rue Cabanis 1
75014 Paris
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)