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MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs

Fact Sheet

Reporting

Results

Objective

The concept behind MOZART is to develop a library of inorganic nanomatrices to be used as smart platforms for effective, non-invasive and highly targeted therapies. MOZART will address, as proof of concept, nanomatrices to treat delayed bone healing and non-healing chronic skin wounds, which are both characterised by an inflammation and often infection. Mesoporous therapeutic glasses (MTGs), doped with selected ions (e.g. Ag+, Li+, Cu2+, Sr2+, Ce3+, B3+) and having nanopores of adjustable size within 2-50 nm, will be synthesised and then loaded with the chosen payload. Ordered mesoporous carbons (OMCs) will also be manufactured to host a wide range of biomolecules and higher payload. As in an orchestra, where the integration among the different participants allows a harmonious symphony to be created, in MOZART the synergistic release of ions and drugs will be directed to achieve a radically improved therapeutic effect. The exploitation of the response of self-immolative polymer coatings upon pH changes will be used as an elegant and effective way for triggering the payload release. The (coated) nanomatrices will be incorporated in a thermosensitive gel that is liquid at room temperature and undergoes sol-gel transition in the physiological environment. These gels are perfect candidates to develop non-invasive procedures to introduce MOZART nanomatrices to the pathological site and keep them in place for the required time. Clinical and societal impacts of MOZART will be enormous, considering the extraordinarily high number of pathological cases potentially involved. Only in EU, 350 000 patients per year are affected by non-union bone fractures and 2.2 million people suffer from chronic wounds. We expect that MOZART approaches will significantly reduce the healing time of non-union bone fractures (within 4 months vs. a minimum of 12 months) and will allow at least 50% of people suffering from chronic wounds to heal fully.

Programme(s)

H2020-EU.2.1.2.2. - Ensuring the safe and sustainable development and application of nanotechnologies

H2020-EU.2.1.2.5. - Developing and standardisation of capacity-enhancing techniques, measuring methods and equipment

H2020-EU.2.1.2.3. - Developing the societal dimension of nanotechnology

Topic(s)

NMP-06-2015 - Novel nanomatrices and nanocapsules

Call for proposal

H2020-NMP-PILOTS-2015

See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

POLITECNICO DI TORINO

Address

Corso Duca Degli Abruzzi 24
10129 Torino

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 925 000

Website

Contact the organisation

Participants (10)

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FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG

Germany

EU Contribution

€ 381 975

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

EU Contribution

€ 265 000

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""

Greece

EU Contribution

€ 369 300

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 709 000

THE UNIVERSITY OF SHEFFIELD

United Kingdom

EU Contribution

€ 500 930

NANOLITH SVERIGE AB

Sweden

EU Contribution

€ 321 898,75

NOBIL BIO RICERCHE SRL

Italy

EU Contribution

€ 322 500

ASHLAND SPECIALTIES IRELAND LIMITED

Ireland

EU Contribution

€ 536 875

CELLOGIC GMBH

Germany

EU Contribution

€ 93 750

DELSITECH OY

Finland

EU Contribution

€ 225 000

Project information

MOZART

Grant agreement ID: 685872

Project website

Status

Ongoing project

Start date

1 November 2015
End date

31 October 2019

Funded under:

H2020-EU.2.1.2.2.

H2020-EU.2.1.2.5.

H2020-EU.2.1.2.3.

Overall budget:

€ 4 651 228,75
EU contribution

€ 4 651 228,75

Coordinated by:

POLITECNICO DI TORINO

Italy

Periodic Reporting for period 2 - MOZART (MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs)

Reporting period: 2017-05-01 to 2018-10-31

Summary of the context and overall objectives of the project

In pathological situations where bacterial infection is a common, often highly serious complication (e.g. osteomyelitis following bone reconstructive surgery and infected chronic wounds), conventional treatments include systemic antibiotic administration, surgical debridement, wound drainage and implant removal (if present). The over-use of antibiotics (with the development of antibiotic resistance) is a world-wide problem hence the drive for alternative antimicrobials is a must.
5-10% of the overall fractures result in a delayed bone healing or in a non –union fracture. The current clinical approach is not always successful and patients may suffer from extra surgeries and may experience disability and pain.
The strategy proposed in MOZART to solve these problems is the introduction of a local, dual ion/drug release smart system into the injured site to improve the therapy. Hence, the objective of the MOZART project is to develop a library of innovative nanomatrices to be used as a smart platform technology for effective, highly targeted therapies in the biomedical field.
The advantages of such a treatment include a synergistic effect between ions and biomolecules released from the biomaterial, high delivery efficiency, continuous action in situ, fine control of the amount of therapeutic agents incorporated (and released), reduced toxicity and overall convenience to the patients. As proof of concept, the MOZART project will address two well-defined and global clinical challenges, i.e. non-healing bone and chronic non-healing skin wounds.
In such pathological states, with particular reference to wound infection, an endogenous pH value change due to inflammatory or hypoxic conditions is likely to be present and can be used to trigger the drug release.
In MOZART the synergistic release of ions and drugs will be directed to achieve radical improvement in therapy for those patients with chronic skin wounds that fail to heal and bone healing defects that resist conventional therapy. Both these fields involve a very large patient numbers which are increasing with an ageing population.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

Project logo

The MOZART platform of nanomatrices

Project information

MOZART

Grant agreement ID: 685872

Project website

Status

Ongoing project

Start date

1 November 2015
End date

31 October 2019

Funded under:

H2020-EU.2.1.2.2.

H2020-EU.2.1.2.5.

H2020-EU.2.1.2.3.

Overall budget:

€ 4 651 228,75
EU contribution

€ 4 651 228,75

Coordinated by:

POLITECNICO DI TORINO

Deliverables

Deliverables not available

Publications

Peer reviewed articles (8)

Tuning mesoporous silica dissolution in physiological environments: a review

Author(s): Juan L. Paris, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano, María Vallet-Regí

Published in: Journal of Materials Science, 2017, ISSN 0022-2461

DOI: 10.1007/s10853-017-0787-1

Hybrid injectable platforms for the in situ delivery of therapeutic ions from mesoporous glasses

Author(s): C. Pontremoli, M. Boffito, S. Fiorilli, R. Laurano, A. Torchio, A. Bari, C. Tonda-Turo, G. Ciardelli, C. Vitale-Brovarone

Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 103-113, ISSN 1385-8947

DOI: 10.1016/j.cej.2018.01.073

Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review

Author(s): Francesco Baino, Sonia Fiorilli, Chiara Vitale-Brovarone

Published in: Bioengineering, Issue 4/1, 2017, Page(s) 15, ISSN 2306-5354

DOI: 10.3390/bioengineering4010015

Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration

Author(s): Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giorgia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale-Brovarone

Published in: Acta Biomaterialia, 2017, ISSN 1742-7061

DOI: 10.1016/j.actbio.2017.04.012

Comparison of the effects of 45S5 and 1393 bioactive glass microparticles on hMSC behavior

Author(s): Taimoor H. Qazi, Shahzad Hafeez, Jochen Schmidt, Georg N. Duda, Aldo R. Boccaccini, Evi Lippens

Published in: Journal of Biomedical Materials Research Part A, Issue 105/10, 2017, Page(s) 2772-2782, ISSN 1549-3296

DOI: 10.1002/jbm.a.36131

The haematoma and its role in bone healing

Author(s): H. Schell, G. N. Duda, A. Peters, S. Tsitsilonis, K. A. Johnson, K. Schmidt-Bleek

Published in: Journal of Experimental Orthopaedics, Issue 4/1, 2017, ISSN 2197-1153

DOI: 10.1186/s40634-017-0079-3

Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

Author(s): M. Gisbert-Garzaran, D. Lozano, M. Vallet-Regí, M. Manzano

Published in: RSC Adv., Issue 7/1, 2017, Page(s) 132-136, ISSN 2046-2069

DOI: 10.1039/C6RA26771H

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Author(s): Miguel Gisbert-Garzarán, Miguel Manzano, María Vallet-Regí

Published in: Bioengineering, Issue 4/1, 2017, Page(s) 3, ISSN 2306-5354

DOI: 10.3390/bioengineering4010003

Project information

MOZART

Grant agreement ID: 685872

Project website

Status

Ongoing project

Start date

1 November 2015
End date

31 October 2019

Funded under:

H2020-EU.2.1.2.2.

H2020-EU.2.1.2.5.

H2020-EU.2.1.2.3.

Overall budget:

€ 4 651 228,75
EU contribution

€ 4 651 228,75

Coordinated by:

POLITECNICO DI TORINO

Project information

MOZART

Grant agreement ID: 685872

Project website

Status

Ongoing project

Start date

1 November 2015
End date

31 October 2019

Funded under:

H2020-EU.2.1.2.2.

H2020-EU.2.1.2.5.

H2020-EU.2.1.2.3.

Overall budget:

€ 4 651 228,75
EU contribution

€ 4 651 228,75

Coordinated by:

POLITECNICO DI TORINO

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Last update: 10 June 2019

Record number: 198810

CORDIS

Objective

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Participants (10)

Project information

Periodic Reporting for period 2 - MOZART (MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs)

Project information

Deliverables

Publications

Project information

Project information

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