Objective
The concept behind MOZART is to develop a library of inorganic nanomatrices to be used as smart platforms for effective, non-invasive and highly targeted therapies. MOZART will address, as proof of concept, nanomatrices to treat delayed bone healing and non-healing chronic skin wounds, which are both characterised by an inflammation and often infection. Mesoporous therapeutic glasses (MTGs), doped with selected ions (e.g. Ag+, Li+, Cu2+, Sr2+, Ce3+, B3+) and having nanopores of adjustable size within 2-50 nm, will be synthesised and then loaded with the chosen payload. Ordered mesoporous carbons (OMCs) will also be manufactured to host a wide range of biomolecules and higher payload. As in an orchestra, where the integration among the different participants allows a harmonious symphony to be created, in MOZART the synergistic release of ions and drugs will be directed to achieve a radically improved therapeutic effect. The exploitation of the response of self-immolative polymer coatings upon pH changes will be used as an elegant and effective way for triggering the payload release. The (coated) nanomatrices will be incorporated in a thermosensitive gel that is liquid at room temperature and undergoes sol-gel transition in the physiological environment. These gels are perfect candidates to develop non-invasive procedures to introduce MOZART nanomatrices to the pathological site and keep them in place for the required time. Clinical and societal impacts of MOZART will be enormous, considering the extraordinarily high number of pathological cases potentially involved. Only in EU, 350 000 patients per year are affected by non-union bone fractures and 2.2 million people suffer from chronic wounds. We expect that MOZART approaches will significantly reduce the healing time of non-union bone fractures (within 4 months vs. a minimum of 12 months) and will allow at least 50% of people suffering from chronic wounds to heal fully.
Fields of science
- medical and health sciencesclinical medicinesurgery
- natural scienceschemical sciencesinorganic chemistrytransition metals
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- humanitiesartsmusicology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Programme(s)
- H2020-EU.2.1.2. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies Main Programme
- H2020-EU.2.1.2.2. - Ensuring the safe and sustainable development and application of nanotechnologies
- H2020-EU.2.1.2.5. - Developing and standardisation of capacity-enhancing techniques, measuring methods and equipment
- H2020-EU.2.1.2.3. - Developing the societal dimension of nanotechnology
Funding Scheme
RIA - Research and Innovation action
Coordinator
10129 Torino
Italy
See on map
Participants (10)
91054 Erlangen
See on map
28040 Madrid
See on map
15341 Agia Paraskevi
See on map
10117 Berlin
See on map
S10 2TN Sheffield
See on map
168 41 Bromma
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
25062 Concesio
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
N91 F6PD Mullingar, Westmeath
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
12159 Berlin
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20520 Turku
See on map