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MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs

Objective

The concept behind MOZART is to develop a library of inorganic nanomatrices to be used as smart platforms for effective, non-invasive and highly targeted therapies. MOZART will address, as proof of concept, nanomatrices to treat delayed bone healing and non-healing chronic skin wounds, which are both characterised by an inflammation and often infection. Mesoporous therapeutic glasses (MTGs), doped with selected ions (e.g. Ag+, Li+, Cu2+, Sr2+, Ce3+, B3+) and having nanopores of adjustable size within 2-50 nm, will be synthesised and then loaded with the chosen payload. Ordered mesoporous carbons (OMCs) will also be manufactured to host a wide range of biomolecules and higher payload. As in an orchestra, where the integration among the different participants allows a harmonious symphony to be created, in MOZART the synergistic release of ions and drugs will be directed to achieve a radically improved therapeutic effect. The exploitation of the response of self-immolative polymer coatings upon pH changes will be used as an elegant and effective way for triggering the payload release. The (coated) nanomatrices will be incorporated in a thermosensitive gel that is liquid at room temperature and undergoes sol-gel transition in the physiological environment. These gels are perfect candidates to develop non-invasive procedures to introduce MOZART nanomatrices to the pathological site and keep them in place for the required time. Clinical and societal impacts of MOZART will be enormous, considering the extraordinarily high number of pathological cases potentially involved. Only in EU, 350 000 patients per year are affected by non-union bone fractures and 2.2 million people suffer from chronic wounds. We expect that MOZART approaches will significantly reduce the healing time of non-union bone fractures (within 4 months vs. a minimum of 12 months) and will allow at least 50% of people suffering from chronic wounds to heal fully.
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Coordinator

POLITECNICO DI TORINO

Address

Corso Duca Degli Abruzzi 24
10129 Torino

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 925 000

Participants (10)

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FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG

Germany

EU Contribution

€ 381 975

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

EU Contribution

€ 265 000

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""

Greece

EU Contribution

€ 369 300

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 709 000

THE UNIVERSITY OF SHEFFIELD

United Kingdom

EU Contribution

€ 500 930

NANOLITH SVERIGE AB

Sweden

EU Contribution

€ 321 898,75

NOBIL BIO RICERCHE SRL

Italy

EU Contribution

€ 322 500

ASHLAND SPECIALTIES IRELAND LIMITED

Ireland

EU Contribution

€ 536 875

CELLOGIC GMBH

Germany

EU Contribution

€ 93 750

DELSITECH OY

Finland

EU Contribution

€ 225 000

Project information

Grant agreement ID: 685872

Status

Ongoing project

  • Start date

    1 November 2015

  • End date

    31 October 2019

Funded under:

H2020-EU.2.1.2.2.

H2020-EU.2.1.2.5.

H2020-EU.2.1.2.3.

  • Overall budget:

    € 4 651 228,75

  • EU contribution

    € 4 651 228,75

Coordinated by:

POLITECNICO DI TORINO

Italy