Objetivo Translating intracellular delivery to the marketThe advent of nanotechnology allowed the combination of new chemical and physical tools to engineer carriers able to perform specific functions at the molecular level. In recent years the ERC award ERC-STG-MEViC, helped to develop a powerful new technology called EndoNaut. This can be used to encapsulate and deliver dyes, imaging and contrast agents and drugs. EndoNaut technology consists of pH sensitive polymeric vesicles with the unique characteristics of endosomal delivery whilst maintaining cell viability and metabolic activity. The core technology, is based on the assembly in water of diblock copolymer poly(2-(methacryloyloxy)ethyl phosphorylcholine)–poly(2-(di-isopropylamino)ethyl methacrylate) (PMPC–PDPA) into vesicles (also known as polymersomes). These nanoscopic carriers enable the encapsulation of both hydrophilic and hydrophobic compounds including large biological macromolecules. Intracellular delivery is of prime importance for several applications and it can enhance existing therapies as well as allowing new ones. It is not surprising that EndoNaut is now generating significant commercial interest from several our collaborating pharmaceutical and non-pharmaceutical partners.There are two major areas of application for EndoNaut that offer opportunity for short term commercialisation. The first application is as a reagent in life science research and the second is as screening platform for new chemical entities libraries of pharmaceutical companies with few or no other option to deliver their molecules. The world market for both intracellular reagents and high-throughput screening are predicted to grow yearly by 8-9% generating revenue in the order of billions of USD (PRNewswire). The aim of this project is to form a new company dedicated to the exploitation of EndoNaut technology. The current grant would be enabling in the translation process from laboratory to market. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsengineering and technologynanotechnology Programa(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Tema(s) ERC-PoC-2015 - ERC Proof of Concept Grant Convocatoria de propuestas ERC-2015-PoC Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-POC - Proof of Concept Grant Institución de acogida UNIVERSITY COLLEGE LONDON Aportación neta de la UEn € 149 929,00 Dirección GOWER STREET WC1E 6BT London Reino Unido Ver en el mapa Región London Inner London — West Camden and City of London Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 149 929,00 Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo UNIVERSITY COLLEGE LONDON Reino Unido Aportación neta de la UEn € 149 929,00 Dirección GOWER STREET WC1E 6BT London Ver en el mapa Región London Inner London — West Camden and City of London Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 149 929,00
