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New Quaternary Ammonium Salts for use in Drug Manufacture

New Quaternary Ammonium Salts for use in Drug Manufacture

Objective

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to develop three new categories of quaternary ammonium salts to be used as catalysts for the cost-efficient and green manufacture of high value active pharmaceutical ingredients.
In order to achieve this objective the proposal brings together 3 partners with complementary skills:
University of Naples(UNIN): experts in the preparation and purification of cyclic peptides. Experts in solid phase synthesis and immobilisation of peptides on solid support.
KelAda Pharmachem: Phase transfer catalysis/organo catalysis/scale-up of chemical processes
University of Linz(JKU Linz): experts in design of new ammonium salts and optimisation of enantioselective phase transfer catalyses.

We have broken this proposal into the following separate Work Packages:
WP1. Preparation of new designer ammonium salts [WP leader: Kelada]
WP2. Preparation of cyclic peptide based ammonium salts [WP leader: UNINA]
WP3. Evaluation of new ammonium salt catalysts prepared through WP1 [WP JKULinz]
WP4. Evaluation of new Ammonium salt catalysts prepared through WP2[WP leader: UNINA]
WP5. Application of Ammonium salts to drug production [WP leader: Kelada]
WP6. Scale up of key steps or the manufacture of drugs [WP leader: Kelada]
WP 7. Management, Communication & Dissemination [WP leader: KelAda]

The above WP’s will be undertaken via a series of interlinked secondment of researchers between consortium partners and will be complemented by a series of training and other initiatives to facilitate interdisciplinary and intersectoral knowledge sharing and exchange.
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Coordinator

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Address

Corso Umberto I, 40
80138 Napoli

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 432 000

Participants (2)

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KELADA PHARMACHEM LIMITED

Ireland

EU Contribution

€ 180 000

UNIVERSITAT LINZ

Austria

EU Contribution

€ 162 000

Project information

Grant agreement ID: 690882

Status

Ongoing project

  • Start date

    1 March 2016

  • End date

    29 February 2020

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 774 000

  • EU contribution

    € 774 000

Coordinated by:

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Italy