Cel Funded by the ERC-Starting Grant COMBIPATTERNING, we have conducted proof-of-principle experiments to synthesize peptide arrays with a density of up 25 Mio spots per cm2 (2 µm pitch). With these spot densities, a microscope slide would display more than a Billion different peptide spots, which is comparable to phage display technologies. Therefore, we want to verify the innovation potential of our novel very-high-density peptide arrays that should find a market in all kinds of applications where pre-screening of large peptide libraries is done. We think our novel PreScreenArrays should do much better than currently available display technologies and chemical compound libraries due to the following features: (a) The manufacturing cost of PreScreenArrays will be unprecedentedly low, (b) very small sample volumes, e.g. antibody sera can be analysed with our densely packed arrays, (c) we are fast and cheap in analysing the peptide arrays for binders since we don’t need any readout (we know the peptide’s sequence at every spot), (d) we can easily build into PreScreenArrays all kinds of artificial building blocks, e.g. posttranslational modifications of amino acids (which is a huge advantage over all display technologies), (e) we can easily synthesize focused libraries (i.e. some amino acids are fixed, while others are varied, e.g. to screen for improved antibiotic peptides), and (f) we can easily synthesize cyclic peptides that – similar to chemical compound libraries – should yield high-affinity binders for target proteins (cyclic peptides fold into fewer 3D structures when compared to linear peptides). We think that these features translate into a highly competitive technology, when compared to display techniques, and, eventually, also to chemical compound libraries. Dziedzina nauki natural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical sciencesopticsmicroscopynatural scienceschemical sciencesorganic chemistryamines Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-PoC-2015 - ERC Proof of Concept Grant Zaproszenie do składania wniosków ERC-2015-PoC Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-POC - Proof of Concept Grant Instytucja przyjmująca KARLSRUHER INSTITUT FUER TECHNOLOGIE Wkład UE netto € 147 247,00 Adres KAISERSTRASSE 12 76131 Karlsruhe Niemcy Zobacz na mapie Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 147 247,00 Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko KARLSRUHER INSTITUT FUER TECHNOLOGIE Niemcy Wkład UE netto € 147 247,00 Adres KAISERSTRASSE 12 76131 Karlsruhe Zobacz na mapie Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 147 247,00
