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Next generation sepsis diagnosis

Objective

Sepsis is a potentially fatal condition that arises when the body’s response to an infection damages its own tissues and organs. It is mainly caused by bacteria and fungi, which spread through the blood circulation. It is one of the biggest public health issue in the EU and worldwide due to its high incidence, mortality, human and economic cost. Early diagnosis is crucial to the management of sepsis, as every hour of delay of appropriate antibiotic therapy increases mortality by 5-10%.
Unfortunately, sepsis diagnosis remains one of the greatest clinical challenges in critical care. Current diagnostic methods, including blood culture and different nucleic acid based multiplex technologies, are impaired by the significant time-delay of 1-2 days and/or low sensitivity of 30-50%. Hence there is an urgent need to develop new diagnostic tools that can provide more accurate and earlier sepsis diagnosis, so that patients with sepsis can be administered with rapid and correct initial antimicrobial treatment.
The SMARTDIAGNOS project will advance sepsis diagnosis by simplifying clinical sample analysis methods and integrating the currently required numerous steps into a single streamlined device. This will be achieved by combining a number of innovative technologies: 1) 3-dimentional sample concentration to process large amount of raw sample; 2) direct PCR in the 3D microstructure to circumvent DNA extraction step; 3) solid-phase PCR to achieve unlimited multiplexing capability; 4) supercritical angle fluorescence (SAF) microlens array for enhanced fluorescence detection and precise quantification of sepsis-related pathogens.
The SMARTDIAGNOS system will go beyond the state of the art for shorter time (1-3 h), higher sensitivity (95%), higher selectivity (99%), multiplexing capability, antimicrobial resistance profiling, and automation. Fast and correct sepsis diagnosis will improve patient outcome, shorten intensive care stay and thus reduce health costs.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid
  • /medical and health sciences/health sciences/public and environmental health
  • /social sciences/sociology/industrial relations/automation
  • /natural sciences/biological sciences/microbiology/mycology
  • /natural sciences/biological sciences/microbiology/mycology/ethnomycology
  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/critical care medicine
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

H2020-ICT-2015
See other projects for this call

Funding Scheme

IA - Innovation action

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 393 615,95

Participants (9)

COPENHAGEN BUSINESS SCHOOL
Denmark
EU contribution
€ 122 955
Address
Solbjerg Plads 3
2000 Frederiksberg
Activity type
Higher or Secondary Education Establishments
TATAA BIOCENTER AB
Sweden
EU contribution
€ 248 624,25
Address
Odinsgatan 28
411 03 Goteborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SCANDINAVIAN MICRO BIODEVICES APS
Denmark
EU contribution
€ 699 953,80
Address
Gammelgardsvej 87C
3520 Farum
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CUBE DX GMBH
Austria
EU contribution
€ 721 122,50
Address
Westbahnstrasse 55
4300 St Valentin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNILABS AB
Sweden
EU contribution
€ 126 250
Address
Box 1061
40522 Goteborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HOGSKOLAN I SKOVDE
Sweden
EU contribution
€ 183 500
Address
Hogskolevagen 1
54 128 Skovde
Activity type
Higher or Secondary Education Establishments
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 130 000
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT FUR WEITERBILDUNG KREMS
Austria
EU contribution
€ 273 550
Address
Dr Karl Dorrek Strasse 30
3500 Krems
Activity type
Higher or Secondary Education Establishments
DIN DEUTSCHES INSTITUT FUER NORMUNG E.V.
Germany
EU contribution
€ 128 337,50
Address
Burggrafenstrasse 6
10787 Berlin
Activity type
Other