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Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes

Objectif

Type 2 diabetes (T2D) is a major public health problem, affecting 55 million European citizens. T2D ensues in individuals who develop a progressive pancreatic beta cell failure. T2D probably comprises a heterogeneous group of diseases. A new molecular taxonomy of T2D is essential for the development of medical care that is predictive, preventive and personalized. Currently available T2D therapies are not disease modifying: they treat hyperglycaemia without addressing its underlying cause, i.e. beta cell failure. In this proposal we seek to identify pathogenic molecular events that operate in the diseased tissue, i.e. the failing human beta cell, at their true level of complexity. T2DSystems will accomplish this ambitious goal by integrating human islet genetic and epigenetic data with disease-relevant environmental perturbations, metabolomics and functional studies, and use this knowledge to identify distinct human islet phenotypes in subgroups of patients. In closely interacting work packages, we will achieve the following goals:
• Compile and expand existing European bio-banks and datasets to create the Translational human pancreatic Islet Genotype tissue-Expression Resource (TIGER), a T2D systems biomedicine resource of unprecedented scale;
• Develop large-scale data analysis tools and both data driven and mechanistic probabilistic modelling frameworks to exploit TIGER towards system level biological insight;
• Translate these findings to identify stratified beta cell phenotypes in human cohorts. This will provide understanding of beta cell pathophysiology in vivo and enable stratified prevention and therapeutics.
T2DSystems will enable the development of personalized diagnostic tests, taking into account individual environmental and genetic risk factors. The newly identified molecular disease mechanisms will provide the basis for development of novel therapies and for patient stratification to test individualized therapies.

Appel à propositions

H2020-PHC-2015-two-stage
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Coordinateur

UNIVERSITE LIBRE DE BRUXELLES
Adresse
Avenue Franklin Roosevelt 50
1050 Bruxelles
Belgique
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 1 504 957,77

Participants (11)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Contribution de l’UE
€ 633 418,75
Adresse
Wellington Square University Offices
OX1 2JD Oxford
Type d’activité
Higher or Secondary Education Establishments
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Participation terminée

Espagne
Contribution de l’UE
€ 402 829,98
Adresse
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Type d’activité
Other
UNIVERSITA DI PISA
Italie
Contribution de l’UE
€ 517 722,50
Adresse
Lungarno Pacinotti 43/44
56126 Pisa
Type d’activité
Higher or Secondary Education Establishments
LUNDS UNIVERSITET
Suède
Contribution de l’UE
€ 589 667,50
Adresse
Paradisgatan 5C
22100 Lund
Type d’activité
Higher or Secondary Education Establishments
KOBENHAVNS UNIVERSITET
Danemark
Contribution de l’UE
€ 488 492,50
Adresse
Norregade 10
1165 Kobenhavn
Type d’activité
Higher or Secondary Education Establishments
BARCELONA SUPERCOMPUTING CENTER-CENTRO NACIONAL DE SUPERCOMPUTACION
Espagne
Contribution de l’UE
€ 451 961,25
Adresse
Calle Jordi Girona 31
08034 Barcelona
Type d’activité
Research Organisations
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Participation terminée

United Kingdom
Contribution de l’UE
€ 118 179
Adresse
South Kensington Campus Exhibition Road
SW7 2AZ London
Type d’activité
Higher or Secondary Education Establishments
INTOMICS AS
Danemark
Contribution de l’UE
€ 471 486,25
Adresse
Lottenborgvej 26
2800 Kgs Lyngby
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SIRION BIOTECH GMBH
Allemagne
Contribution de l’UE
€ 454 500
Adresse
Am Klopferspitz 19
82152 Planegg Martinsried
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
A2F ASSOCIATES LIMITED
United Kingdom
Contribution de l’UE
€ 186 150
Adresse
7 Laureate Paddocks
CB8 0AP Newmarket
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACIO CENTRE DE REGULACIO GENOMICA
Espagne
Contribution de l’UE
€ 179 237
Adresse
Carrer Doctor Aiguader 88
08003 Barcelona
Type d’activité
Research Organisations