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The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe

The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe

Objective

Non-invasively imaging small numbers of molecular probes, to help image particular targets or pathways in vivo, is currently undergoing a technological revolution. Recent breakthroughs in molecular hyperpolarization proved > 10,000-fold increase in sensitivity on conventional magnetic resonance imaging (MRI) systems, thus providing insight into previously unseen metabolic processes with enormous potential for socioeconomic relevant diseases. E.g. pyruvate-based hyperpolarized imaging was clinically demonstrated to be effective for prostate cancer diagnostics in human patients. However, the current state-of-the-art hyperpolarization methods are expensive and cumbersome, limiting the access to hyperpolarization technology, and require long hyperpolarization times of 60-90 minutes per dosage; hyperpolarization probes exhibit short hyperpolarization duration (1-5 minutes), limiting the usage of hyperpolarization to metabolic imaging. A quantum technological breakthrough, Nitrogen-Vacancy defects (NV centres) in diamonds, is set to revolutionize the field of hyperpolarization for both hyperpolarizer and probes.
The primary objective of HYPERDIAMOND is the development and commercialization of two new molecular imaging technologies for sensitive diagnosis and treatment monitoring, based on NV centres:
The Diamond Hyperpolarizer will offer a cost- and time-effective solution for hyperpolarization that easily fits current MRI layouts, hyperpolarizes within 5 minutes, and improves clinical viability. The Nano-diamond (ND) Probe will introduce the first targeted MRI probe capable of achieving comparable molecular sensitivity to positron emission tomography (PET) with MRI systems, exhibiting extremely long hyperpolarization duration (~1 hour), and enabling non-metabolic hyperpolarized imaging.
HYPERDIAMOND will bridge the gap between novel quantum and nanotechnology and their applications in hyperpolarized imaging, producing innovation not feasible with current technology.
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Coordinator

UNIVERSITAET ULM

Address

Helmholtzstrasse 16
89081 Ulm

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 228 891,97

Participants (10)

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THE HEBREW UNIVERSITY OF JERUSALEM

Israel

EU Contribution

€ 200 150

NVISION IMAGING TECHNOLOGIES GMBH

Germany

EU Contribution

€ 685 625

UNIVERSITE DE TOURS

France

EU Contribution

€ 632 353,75

REASERCH FUND OF THE HADASSAH MEDICAL ORGANIZATION (R.A)

Israel

EU Contribution

€ 427 750

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Germany

EU Contribution

€ 390 125

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH

Austria

EU Contribution

€ 379 661,25

LM VAN MOPPES AND SONS SA

Switzerland

ARTTIC

France

EU Contribution

€ 282 580

KANFIT LTD

Israel

EU Contribution

€ 272 805

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 366 108,03

Project information

Grant agreement ID: 667192

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 December 2019

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 5 073 550,25

  • EU contribution

    € 4 866 050

Coordinated by:

UNIVERSITAET ULM

Germany