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Digital Hybrid Breast PET/MRI for Enhanced Diagnosis of Breast Cancer

Objective

Breast cancer represents a leading cause of cancer death in women and a major socio-economic issue. With currently available methods, early diagnosis frequently fails. Moreover, beyond mere detection, there is an ever-increasing need for improved non-invasive characterisation of cancer. Targeted therapies require an in-depth analysis of cancer to select and guide appropriate treatment. Both, PET and MRI can provide molecular and functional information that may be of pivotal importance for tailoring therapy. However, current whole-body PET/MRI systems lack the necessary sensitivity and resolution for this task. HYPMED addresses this by engineering an innovative imaging tool. HYPMED will integrate an innovative fully-digital MRI-transparent PET-detector into a novel multi-channel PET-transparent MRI surface coil. The PET-RF insert will allow unprecedented imaging of breast cancer with high-resolution/ultra-high sensitivity PET, combined with high-level structural and functional MRI, and allow minimal-invasive MR- and PET-guided targeted biopsy. Moreover with such PET-RF inserts, every regular clinical MR-system can, upon demand, be turned into a hybrid system. We will evaluate the impact of this technology on breast cancer diagnosis, prediction, and monitoring/assessment of treatment response by a carefully designed clinical study that employs established and novel PET tracers in 250 patients. Imaging data will be correlated with established and novel molecular biomarkers; results will be compared to those obtained from whole-body PET/MRI and PET/CT. A multidisciplinary consortium of clinical scientists, 3 SMEs and an industry partner will pave the way for commercialization of HYPMED products for advanced clinical decision making in cancer patients. Once HYPMED is successful, we will expand this approach to other applications such as prostate cancer or cardiac hybrid imaging, and thus introduce a paradigm shift in the field of PET/MR hybrid imaging as a whole.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2015-two-stage

Coordinator

EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Net EU contribution
€ 394 637,50
Non-EU contribution
€ 0,00

Participants (9)

UNIVERSITAETSKLINIKUM AACHEN
Germany
Net EU contribution
€ 1 971 303,75
Address
Pauwelsstrasse 30
52074 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FORSCHUNGSZENTRUM JULICH GMBH
Germany
Net EU contribution
€ 2 500,00
Address
Wilhelm Johnen Strasse
52428 Julich

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Region
Nordrhein-Westfalen Köln Düren
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 309 125,00
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNISCHE UNIVERSITEIT DELFT
Netherlands
Net EU contribution
€ 967 770,00
Address
Stevinweg 1
2628 CN Delft

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Region
West-Nederland Zuid-Holland Delft en Westland
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
Net EU contribution
€ 95 375,00
Address
Schlossplatz 2
48149 Muenster

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Region
Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NORAS MRI PRODUCTS GMBH
Germany
Net EU contribution
€ 595 875,00
Address
Leibnizstrasse 4
97204 Hochberg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Unterfranken Würzburg, Landkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FUTURA COMPOSITES BV
Netherlands
Net EU contribution
€ 1 132 100,00
Address
Marconistraat 40
1704 RG Heerhugowaard

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Region
West-Nederland Noord-Holland Alkmaar en omgeving
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INTRASENSE

Participation ended

France
Net EU contribution
€ 117 967,50
Address
1231 Avenue Du Mondial 98
34000 Montpellier

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PHILIPS ELECTRONICS NEDERLAND BV
Netherlands
Net EU contribution
€ 275 303,75
Address
High Tech Campus 52
5656 AG Eindhoven

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Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00