Skip to main content

Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders

Objective

COSYN integrates outstanding European academic and three large Pharma to exploit genomic findings for intellectual disability (ID), autism, and schizophrenia. We capitalise on comorbidity, from clinic to cells and synapses, and have access to large existing samples. We focus on rare genetic variants of strong effect in patients with clinical comorbidity.
Our aims are: (1) Understand comorbidity by comparing symptom and syndrome overlap with novel neurobiological criteria; (2) Elucidate mechanisms of comorbidity using neurobiology for the major genomic clue of synaptic dysfunction to unravel the cellular mechanisms of comorbidity; (3) Generate novel neuronal cell models by using advanced technologies to make neurons from carefully selected patients, and use genome editing to create or correct genetic variants. Multiple advanced neuroscience platforms are in place to evaluate an extensive set of molecular and cellular parameters, and to identify alterations in synaptic biology characteristic of ID, autism, and schizophrenia. These cellular models will, with Pharma partners, be up-scaled to provide “industry-standard” cellular assays for compound screening; (4) Refine diagnostic tools, use novel genomic and cellular features to improve disease classification and discriminate specific patient subtypes; and (5) Case studies in precision medicine: with Pharma partners, identify patients with a genetic change whose consequences can be reproducibly ameliorated in vitro by an approved medication. Recommend to the patient and clinician a double-blinded, N-of-one crossover case study to evaluate the clinical utility of a medication precisely indicated for that person.
COSYN is an integrated, state-of-art, bench-to-bedside programme focused on personalised therapeutics. COSYN is a crucial next step in “decoding” the genetic findings via intensive focus on the clinical and molecular comorbidities of ID, autism, and schizophrenia.

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 675 000

Participants (13)

INSTITUT PASTEUR
France
EU contribution
€ 225 000
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 800 000
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 600 000
Address
Venusberg-campus 1
53127 Bonn
Activity type
Higher or Secondary Education Establishments
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 225 000
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 225 000
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
STICHTING VU
Netherlands
EU contribution
€ 1 925 000
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
REGION HOVEDSTADEN
Denmark
EU contribution
€ 75 000
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SYNAPTOLOGICS BV
Netherlands
EU contribution
€ 650 000
Address
Achillesstraat 28 2
1008 BA Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CEGAT GMBH
Germany
EU contribution
€ 100 000
Address
Paul Ehrlich Strasse 17
72076 Tubingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LIFE AND BRAIN GMBH
Germany
EU contribution
€ 300 000
Address
Venusberg-campus 1
53127 Bonn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
H. LUNDBECK AS
Denmark
EU contribution
€ 75 000
Address
Ottiliavej 7-9
2500 Valby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
F. HOFFMANN-LA ROCHE AG
Switzerland
EU contribution
€ 0
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
VERENIGING SAMENWERKENDE OUDER- EN PATIENTENORGANISATIES
Netherlands
EU contribution
€ 50 000
Address
Vredehofstraat 31
3761HA Soest
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)