Project description DEENESFRITPL Mechanistic insight into attention-deficit/hyperactivity disorder comorbid conditions Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition that has a high co-occurrence with anxiety, depression, substance use and obesity across generations. Shared genetic risk factors, particularly related to the dopamine system, suggest a genetic link among these psychiatric disorders. The EU-funded CoCA project aims to investigate the underlying mechanisms of comorbidities using epidemiologic and genetic approaches. Researchers will assess the burden and socioeconomic impact, identify risk factors, study biological pathways and develop biomarkers. They will also conduct a clinical trial on non-pharmacological treatments with the help of mobile health technology. Key project objectives include early detection, prevention and affordable treatment with immediate societal benefits. Show the project objective Hide the project objective Objective Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders, and a highly prevalent somatic disease, obesity. ADHD, a childhood-onset disorder, forms the entry into a lifelong negative trajectory characterized by these comorbidities. Common mechanisms underlying this course are unknown, despite their relevance for early detection, prevention, and treatment. Our interdisciplinary team of experts will integrate epidemiologic/genetic approaches with experimental designs to address those issues. We will determine disease burden of comorbidity, calculate its socioeconomic impact, and reveal risk factors. We will study biological pathways of comorbidity and derive biomarkers, prioritizing two candidate mechanisms (circadian rhythm and dopaminergic neurotransmission), but also leveraging large existing data sets to identify new ones. A pilot clinical trial to study non-pharmacologic, dopamine-based and chronobiological treatments will be performed, employing innovative mHealth to monitor and support patients’ daily life. Integration of findings will lead to prediction algorithms enhancing early diagnosis and prevention of comorbidity. Finally, we will screen to repurpose existing pharmacological compounds. Integrating complementary approaches based on large-scale, existing data and innovative data collection, we maximize value for money in this project, leading to insight into the mechanisms underlying this comorbidity triad with its huge burden for healthcare, economy, and society. This will facilitate early detection and non-invasive, scalable, and low-cost treatment, creating opportunities for substantial and immediate societal impact. Fields of science medical and health sciencesclinical medicinepsychiatrymedical and health sciencesbasic medicinephysiologypathophysiologymedical and health scienceshealth sciencespersonalized medicinemedical and health scienceshealth sciencesnutritionobesity Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.1. - Understanding health, wellbeing and disease Topic(s) PHC-03-2015 - Understanding common mechanisms of diseases and their relevance in co-morbidities Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2015-two-stage Funding Scheme RIA - Research and Innovation action Coordinator JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Net EU contribution € 996 897,50 Address THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main Germany See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 996 897,50 Participants (17) Sort alphabetically Sort by Net EU contribution Expand all Collapse all STICHTING RADBOUD UNIVERSITEIT Participation ended Netherlands Net EU contribution € 0,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data ACADEMISCH ZIEKENHUIS GRONINGEN Netherlands Net EU contribution € 262 000,00 Address HANZEPLEIN 1 9713 GZ Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 262 000,00 KAROLINSKA INSTITUTET Sweden Net EU contribution € 202 000,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 202 000,00 UNIVERSITAT DE BARCELONA Spain Net EU contribution € 252 391,25 Address GRAN VIA DE LES CORTS CATALANES 585 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 252 391,25 FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA Spain Net EU contribution € 326 996,25 Address PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA 08035 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 326 996,25 UNIVERSITATSMEDIZIN ROSTOCK Germany Net EU contribution € 240 000,00 Address SCHILLINGALLEE 35 18055 Rostock See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Rostock, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 240 000,00 KING'S COLLEGE LONDON United Kingdom Net EU contribution € 589 000,00 Address STRAND WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 589 000,00 UNIVERSITATSKLINIKUM HEIDELBERG Germany Net EU contribution € 339 657,50 Address IM NEUENHEIMER FELD 672 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 339 657,50 TARTU ULIKOOL Estonia Net EU contribution € 147 000,00 Address ULIKOOLI 18 51005 Tartu See on map Region Eesti Eesti Lõuna-Eesti Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 147 000,00 KARLSRUHER INSTITUT FUER TECHNOLOGIE Germany Net EU contribution € 466 913,00 Address KAISERSTRASSE 12 76131 Karlsruhe See on map Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 466 913,00 UNIVERSIDAD DE GRANADA Spain Net EU contribution € 105 000,00 Address CUESTA DEL HOSPICIO SN 18071 Granada See on map Region Sur Andalucía Granada Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 105 000,00 UNIVERSITETET I BERGEN Norway Net EU contribution € 402 360,00 Address MUSEPLASSEN 1 5020 Bergen See on map Region Norge Vestlandet Vestland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 596 110,00 THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK United States Net EU contribution € 312 000,00 Address STATE STREET 35 12201 Albany Ny See on map Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 312 000,00 AARHUS UNIVERSITET Denmark Net EU contribution € 261 805,00 Address NORDRE RINGGADE 1 8000 Aarhus C See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 261 805,00 HGC HEALTHCARE CONSULTANTS GMBH Germany Net EU contribution € 150 000,00 Address GRAF-ADOLF PLATZ 15 40213 DUSSELDORF See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 150 000,00 CONCENTRIS RESEARCH MANAGEMENT GMBH Germany Net EU contribution € 360 000,00 Address Ludwigstr. 4 82256 FURSTENFELDBRUCK See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Oberbayern Fürstenfeldbruck Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 360 000,00 STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM Netherlands Net EU contribution € 585 000,00 Address GEERT GROOTEPLEIN 10 ZUID 6525 GA Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 585 000,00