CORDIS
EU research results

CORDIS

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Comorbid Conditions of Attention deficit / hyperactivity disorder

Project information

Grant agreement ID: 667302

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 December 2020

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 6 192 770,50

  • EU contribution

    € 5 999 020,50

Coordinated by:

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany

Objective

Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders, and a highly prevalent somatic disease, obesity. ADHD, a childhood-onset disorder, forms the entry into a lifelong negative trajectory characterized by these comorbidities. Common mechanisms underlying this course are unknown, despite their relevance for early detection, prevention, and treatment. Our interdisciplinary team of experts will integrate epidemiologic/genetic approaches with experimental designs to address those issues. We will determine disease burden of comorbidity, calculate its socioeconomic impact, and reveal risk factors. We will study biological pathways of comorbidity and derive biomarkers, prioritizing two candidate mechanisms (circadian rhythm and dopaminergic neurotransmission), but also leveraging large existing data sets to identify new ones. A pilot clinical trial to study non-pharmacologic, dopamine-based and chronobiological treatments will be performed, employing innovative mHealth to monitor and support patients’ daily life. Integration of findings will lead to prediction algorithms enhancing early diagnosis and prevention of comorbidity. Finally, we will screen to repurpose existing pharmacological compounds. Integrating complementary approaches based on large-scale, existing data and innovative data collection, we maximize value for money in this project, leading to insight into the mechanisms underlying this comorbidity triad with its huge burden for healthcare, economy, and society. This will facilitate early detection and non-invasive, scalable, and low-cost treatment, creating opportunities for substantial and immediate societal impact.
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Coordinator

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Address

Theodor W Adorno Platz 1
60323 Frankfurt Am Main

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 991 897,50

Participants (16)

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 610 000

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 262 000

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 202 000

UNIVERSITAT DE BARCELONA

Spain

EU Contribution

€ 252 391,25

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA

Spain

EU Contribution

€ 326 996,25

UNIVERSITATSMEDIZIN ROSTOCK

Germany

EU Contribution

€ 240 000

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 569 000

UNIVERSITATSKLINIKUM HEIDELBERG

Germany

EU Contribution

€ 339 657,50

TARTU ULIKOOL

Estonia

EU Contribution

€ 147 000

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Germany

EU Contribution

€ 466 913

UNIVERSIDAD DE GRANADA

Spain

EU Contribution

€ 105 000

UNIVERSITETET I BERGEN

Norway

EU Contribution

€ 402 360

THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

United States

EU Contribution

€ 312 000

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 261 805

HGC GESUNDHEITSCONSULT GMBH

Germany

EU Contribution

€ 150 000

Concentris Research Management GmbH

Germany

EU Contribution

€ 360 000

Project information

Grant agreement ID: 667302

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 December 2020

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 6 192 770,50

  • EU contribution

    € 5 999 020,50

Coordinated by:

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany