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Common mechanisms and pathways in Stroke and Alzheimer's disease.

Objective

Common mechanisms and pathways in Stroke and Alzheimer's disease.
It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD.
This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 098 750

Participants (10)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 476 228,75
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 509 946,25
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Austria
EU contribution
€ 323 750
Address
Am Gestade 1
1010 Wien
Activity type
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 510 000
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 256 250
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
MIMETAS BV
Netherlands
EU contribution
€ 509 625
Address
Jh Oortweg 19
2333CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT PASTEUR DE LILLE FONDATION
France
EU contribution
€ 324 875
Address
Rue Du Professeur Calmette 1
59019 Lille
Activity type
Research Organisations
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 409 510
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 0
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE BORDEAUX
France
EU contribution
€ 171 250
Address
Place Pey Berland 35
33000 Bordeaux
Activity type
Higher or Secondary Education Establishments