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Common mechanisms and pathways in Stroke and Alzheimer's disease.

Common mechanisms and pathways in Stroke and Alzheimer's disease.

Objective

Common mechanisms and pathways in Stroke and Alzheimer's disease.
It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD.
This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.
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Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Address

Dr Molewaterplein 40
3015 Gd Rotterdam

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 098 750

Participants (10)

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KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 476 228,75

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 509 946,25

EIBIR GEMEINNUETZIGE GMBH ZUR FOERDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG

Austria

EU Contribution

€ 323 750

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 510 000

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 256 250

MIMETAS BV

Netherlands

EU Contribution

€ 509 625

INSTITUT PASTEUR DE LILLE FONDATION

France

EU Contribution

€ 324 875

UNIVERSITEIT LEIDEN

Netherlands

EU Contribution

€ 409 510

UNIVERSITE DE GENEVE

Switzerland

UNIVERSITE DE BORDEAUX

France

EU Contribution

€ 171 250

Project information

Grant agreement ID: 667375

Status

Ongoing project

  • Start date

    1 December 2015

  • End date

    30 November 2020

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 5 100 372,50

  • EU contribution

    € 4 590 185

Coordinated by:

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands