CORDIS
EU research results

CORDIS

English EN

Development of closed, scalable and AUTOmated robotic systems for therapeutic STEM cell manufacturing: aseptic systems from “Donor-to-Patient”

Project information

Grant agreement ID: 667932

Status

Closed project

  • Start date

    1 January 2016

  • End date

    31 December 2018

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 5 995 761,25

  • EU contribution

    € 5 995 761,25

Coordinated by:

NATIONAL UNIVERSITY OF IRELAND GALWAY

Ireland

Objective

AUTOSTEM will develop closed, scaleable and automated systems for therapeutic cell manufacture. The project vision is a donor-to-patient system where all aspects of processing, from tissue harvest to patient delivery are fully closed and aseptic. The process will involve new methods of biological cell selection from marrow, fat or other tissues, bioreactors to achieve scale and media formulations that are fully xeno-free. Process monitoring will utilise remote sensing and the automated retrieval of cells for microscopy, flow cytometry, karyotyping, differentiation or other tests. The final product will be a cryobag containing a specified cell dose, ready for thawing and clinical delivery.

AUTOSTEM will be the factory of the future for therapeutic cell manufacturing. This system could ultimately be scaled for hospital-based use to produce autologous cells or at industrial scale for allogeneic therapy. It will achieve consistent cell production, minimise contamination, maximise scale and reduce cost of goods, thus enabling routine clinical use of cell therapies.

The consortium will be a partnership of academic centres and industry with expertise across the disciplines relevant to the research and development goals. It will also include expertise in GMP and regulatory compliance and in healthcare economic analysis.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY

Address

University Road
H91 Galway

Ireland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 849 375

Participants (9)

UNIVERSITA DEGLI STUDI DI GENOVA

Italy

EU Contribution

€ 450 000

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 1 207 041,25

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Ireland

EU Contribution

€ 757 353,75

PINTAIL LTD

Ireland

EU Contribution

€ 250 000

CROSPON LIMITED

Ireland

EU Contribution

€ 685 000

ZELLWERK GMBH

Germany

EU Contribution

€ 498 750

CELL THERAPY CATAPULT LIMITED

United Kingdom

EU Contribution

€ 299 952,50

ASTON UNIVERSITY

United Kingdom

EU Contribution

€ 549 913,75

ORBSEN THERAPEUTICS LIMITED

Ireland

EU Contribution

€ 448 375

Project information

Grant agreement ID: 667932

Status

Closed project

  • Start date

    1 January 2016

  • End date

    31 December 2018

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 5 995 761,25

  • EU contribution

    € 5 995 761,25

Coordinated by:

NATIONAL UNIVERSITY OF IRELAND GALWAY

Ireland