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Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis

Objective

Bladder cancer is among the most expensive diseases in oncology in terms of treatment costs; each procedure requires days of hospitalisation and recurrence rates are high. Current unmet clinical needs can be addressed by optical methods due to the combination of non-invasive and real-time capture of unprecedented biomedical information.
The MIB objective is to provide robust, easy-to-use, cost-effective optical methods with superior sensitivity and specificity to enable a step-change in point-of-care diagnostics of bladder cancer. The concept relies on combining optical methods (optical coherence tomography, multi-spectral opto-acoustic tomography, shifted excitation Raman difference spectroscopy, and multiphoton microscopy) providing structural, biochemical and functional information. The hypothesis is that such combination enables in situ diagnosis of bladder cancer with superior sensitivity and specificity due to unprecedented combined anatomic, biochemical and molecular tissue information. The step-change is that this hybrid concept is provided endoscopically for in vivo clinical use.
The project relies on development of new light sources, high-speed imaging systems, unique imaging fibre bundles, and endoscopes, combined and applied clinically. The consortium comprises world-leading academic organisations in a strong partnership with innovative SMEs and clinical end-users.
Through commercialization of this novel imaging platform, MIB is expected to reinforce leading market positions in medical devices and healthcare for the SMEs in areas where European industry is already strong. The impact is that improved diagnostic procedures facilitate earlier onset of effective treatment, thus recurrence and follow-up procedures would be reduced by 10%, i.e., reducing costs. Using MIB technology, healthcare cost savings in the order of 360M€ are expected for the whole EU. Equally important, prognosis and patient quality of life would improve drastically.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer/bladder cancer
  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 829 254,50

Participants (10)

FORSCHUNGSVERBUND BERLIN EV
Germany
EU contribution
€ 669 582,50
Address
Rudower Chaussee 17
12489 Berlin
Activity type
Research Organisations
M-SQUARED LASERS LIMITED
United Kingdom
EU contribution
€ 512 500
Address
Venture Building 1 Kelvin Campus Maryhill Road West Of Scotland Science Park
G20 0SP Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 689 078
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Blazejewski MEDI-TECH GMBH
Germany
EU contribution
€ 432 812,50
Address
Elzstrasse 2
79350 Sexau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Germany
EU contribution
€ 653 875
Address
Albert Einstein Strasse 9
07745 Jena
Activity type
Research Organisations
GRINTECH GMBH
Germany
EU contribution
€ 365 475
Address
Schillerstrasse 1
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 479 081,25
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 655 046,25
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
2M ENGINEERING LIMITED
United Kingdom
EU contribution
€ 502 102,50
Address
Sidney Street 80
CT19 6HQ Folkstone
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 195 000
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments