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Paediatric Inflammatory Bowel Diseases Network for Safety, Efficacy, Treatment and Quality improvement of care

Objective

"The incidence of paediatric onset Inflammatory Bowel Diseases (PIBD) has risen dramatically in recent decades. Compared to adult forms, PIBD reflects a more severe disease, more often requiring aggressive treatment with immunomodulators, and thereby exposing children to a life-long risk of serious disease and treatment-related adverse events, such as infections and malignancies. Therefore, there is an urgent need to develop strategies which balance, on an individual basis, therapeutic effectiveness with risks of treatment.
The overall goal of this proposal is to develop and validate a treatment algorithm for PIBD based on high or low risk predictors for early complicated or relapsing disease. This will improve effectiveness, while reducing treatment related risks and life-long complications due to uncontrolled disease progression.

To attain this goal 3 specific aims are proposed under the umbrella of an international network, the ""PIBD-net"":
1) Development of an accessible and feasible risk-stratified treatment algorithm for new onset paediatric IBD on an existing inception cohort and validation in an independent cohort
2) Generation of a prospective large longterm real world inception cohort in a registry designed to analyze effectiveness and safety signals and correlate them to individual risk factors
3) Design and performance of a risk algorithm-based prospective large-scale multicenter randomized clinical trial (RCT) (stratification into high or low risk groups based on specific aim#1) in order to provide optimal personalized therapy : low risk azathioprine vx. methotrexate, high risk : methotrexate vx. adalimumab
This project will translate into the first risk-stratified PIBD treatment algorithms allowing optimization of medical therapy while minimizing treatment-related risk (personalized medicine).

"

Field of science

  • /medical and health sciences/clinical medicine/gastroenterology/inflammatory bowel disease
  • /medical and health sciences/clinical medicine/paediatrics

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITE DE PARIS
Address
85 Bd Saint Germain
75006 Paris
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 580 000

Participants (13)

SHAARE ZEDEK MEDICAL CENTER
Israel
EU contribution
€ 427 338,68
Address
12 Bayit Street Shaare Zedek Medical Center
91031 Jerusalem
Activity type
Other
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 331 750
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 682 980,38
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
VRIJE UNIVERSITEIT BRUSSEL
Belgium
EU contribution
€ 259 720,28
Address
Pleinlaan 2
1050 Brussel
Activity type
Higher or Secondary Education Establishments
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 120 895,41
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
GREATER GLASGOW HEALTH BOARD
United Kingdom
EU contribution
€ 431 459,38
Address
Great Western Road 1055 J B Russell
G12 0XH Glasgow
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
THE FOUNDATION FOR MEDICAL RESEARCH AND DEVELOPMENT OF INFRASTRUCTURES AND HEALTHCARE SERVICES BY THE E WOLSFON MEDICAL CENTER
Israel
EU contribution
€ 176 611,88
Address
62 Halochamin Rd
58100 Holon
Activity type
Other
PEDIATRIC INFLAMATORY BOWEL DISEASES NETWORK PIBD-NET
France
EU contribution
€ 2 539 882,11
Address
Hospital Necker Enfants Malades Service De Gastroenterologie Pediatrique 149 Rue De Sevres
75015 Paris
Activity type
Research Organisations
AIMES GRID SERVICES COMMUNITY INTEREST COMPANY

Participation ended

United Kingdom
EU contribution
€ 51 375
Address
Edge Lane 360 Baird House 2Nd Floor Liverpool Digital Liverpool Innovation Park
L7 9NJ Liverpool
Activity type
Other
DEUTSCHE MORBUS CROHN/COLITIS ULCEROSA VEREINIGUNG BUNDESVERBAND FUR CHRONISCH ENTZUNDLICHE ERKRANKUNGENDES VERDAUUNGSTRAKTES (DCCV) EV
Germany
EU contribution
€ 33 750
Address
Inselstrasse 1
10179 Berlin
Activity type
Other
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 192 861,88
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
VIB VZW
Belgium
EU contribution
€ 150 000
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
AIMES MANAGEMENT SERVICES LIMITED
United Kingdom
EU contribution
€ 17 375
Address
Kilby House Liverpool Innovation Park Edge Lane
L7 9NJ Liverpool
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)