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Imaging the Force of Cancer

Ziel

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recognized as a hallmark of therapeutic efficacy. Currently, there is no non-invasive modality that can directly image these forces in vivo.
Our objective is the non-invasive measurement of both IFP within tumours as well as the forces they exert on their surrounding environment. This will be used to predict a tumour’s metastatic potential and importantly, changes in these forces will be used to predict the therapeutic efficacy of drug therapy. To attain this goal, the biomechanical properties of the tumour and its neighbouring tissue will be measured via MR-elastography at various measured deformation states. Resultant images will be used to reconstruct images of the internal and external forces acting on the tumour. We call this novel imaging modality Magnetic Resonance Force (MRF) imaging .
We will calibrate MRF via cell cultures and pre-clinical models, and then test the method in breast, liver, and brain cancer patients. Thereby, we will investigate whether MRF data can predict metastatic spread and measure IFP in patients. We will also investigate the potential to non-invasively modulate the force environment of cancer cells via externally applied shear forces with the aim of impacting cell motility and proliferation. This can provide novel mechanism for anticancer therapeutic agents via mechanotransduction.

Wissenschaftliches Gebiet

  • /Sozialwissenschaften/Soziologie/Demografie/Sterblichkeit
  • /Medizin- und Gesundheitswissenschaften/Klinische Medizin/Onkologie/Krebs/Brustkrebs

Aufforderung zur Vorschlagseinreichung

H2020-PHC-2015-two-stage
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

RIA - Research and Innovation action

Koordinator

KING'S COLLEGE LONDON
Adresse
Strand
WC2R 2LS London
United Kingdom
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 2 196 560

Beteiligte (15)

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
EU-Beitrag
€ 631 701,25
Adresse
Old Brompton Road 123
SW7 3RP London
Aktivitätstyp
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Schweiz
EU-Beitrag
€ 0
Adresse
Raemistrasse 101
8092 Zuerich
Aktivitätstyp
Higher or Secondary Education Establishments
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Deutschland
EU-Beitrag
€ 515 000
Adresse
Chariteplatz 1
10117 Berlin
Aktivitätstyp
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Frankreich
EU-Beitrag
€ 343 100
Adresse
Rue De Tolbiac 101
75654 Paris
Aktivitätstyp
Research Organisations
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Frankreich
EU-Beitrag
€ 271 020
Adresse
3 Avenue Victoria
75000 Paris
Aktivitätstyp
Research Organisations
UNIVERSITAT BASEL
Schweiz
EU-Beitrag
€ 0
Adresse
Petersplatz 1
4051 Basel
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Higher or Secondary Education Establishments
UNIVERSITETET I OSLO
Norwegen
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€ 731 000
Adresse
Problemveien 5-7
0313 Oslo
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Higher or Secondary Education Establishments
UNIVERSITAET LEIPZIG
Deutschland
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€ 503 500
Adresse
Ritterstrasse 26
04109 Leipzig
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Higher or Secondary Education Establishments
SCREENCELL
Frankreich
EU-Beitrag
€ 322 500
Adresse
10 Avenue Charles Peguy Centre Roger Perez
95200 Sarcelles
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
CERMAKOVA IVA
Deutschland
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€ 150 375
Adresse
Hubschmannstrasse 18
9112 Chemnitz
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
INTEGRATED TECHNOLOGIES LIMITED
United Kingdom
EU-Beitrag
€ 98 500
Adresse
Viking House Ellingham Way
TN23 6NF Ashford
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
PHILIPS MEDICAL SYSTEMS NEDERLAND BV
Niederlande
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€ 0
Adresse
Veenpluis 6
5684 PC Best
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
Frankreich
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€ 0
Adresse
Pierre Brossolette 1
91380 Chilly Mazarin
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF NEW SOUTH WALES
Australien
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€ 0
Adresse
Anzac Parade
2052 Sydney
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Higher or Secondary Education Establishments
THE BRIGHAM AND WOMEN'S HOSPITAL INC
Vereinigte Staaten
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€ 49 375
Adresse
Francis Street 75
02241 Boston Ma
Aktivitätstyp
Research Organisations