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Imaging the Force of Cancer

Objective

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recognized as a hallmark of therapeutic efficacy. Currently, there is no non-invasive modality that can directly image these forces in vivo.
Our objective is the non-invasive measurement of both IFP within tumours as well as the forces they exert on their surrounding environment. This will be used to predict a tumour’s metastatic potential and importantly, changes in these forces will be used to predict the therapeutic efficacy of drug therapy. To attain this goal, the biomechanical properties of the tumour and its neighbouring tissue will be measured via MR-elastography at various measured deformation states. Resultant images will be used to reconstruct images of the internal and external forces acting on the tumour. We call this novel imaging modality Magnetic Resonance Force (MRF) imaging .
We will calibrate MRF via cell cultures and pre-clinical models, and then test the method in breast, liver, and brain cancer patients. Thereby, we will investigate whether MRF data can predict metastatic spread and measure IFP in patients. We will also investigate the potential to non-invasively modulate the force environment of cancer cells via externally applied shear forces with the aim of impacting cell motility and proliferation. This can provide novel mechanism for anticancer therapeutic agents via mechanotransduction.

Field of science

  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

KING'S COLLEGE LONDON
Address
Strand
WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 196 560

Participants (15)

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
EU contribution
€ 631 701,25
Address
Old Brompton Road 123
SW7 3RP London
Activity type
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 0
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 515 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 343 100
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 271 020
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 0
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I OSLO
Norway
EU contribution
€ 731 000
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 503 500
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
SCREENCELL
France
EU contribution
€ 322 500
Address
10 Avenue Charles Peguy Centre Roger Perez
95200 Sarcelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CERMAKOVA IVA
Germany
EU contribution
€ 150 375
Address
Hubschmannstrasse 18
9112 Chemnitz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INTEGRATED TECHNOLOGIES LIMITED
United Kingdom
EU contribution
€ 98 500
Address
Viking House Ellingham Way
TN23 6NF Ashford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PHILIPS MEDICAL SYSTEMS NEDERLAND BV
Netherlands
EU contribution
€ 0
Address
Veenpluis 6
5684 PC Best
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 0
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF NEW SOUTH WALES
Australia
EU contribution
€ 0
Address
Anzac Parade
2052 Sydney
Activity type
Higher or Secondary Education Establishments
THE BRIGHAM AND WOMEN'S HOSPITAL INC
United States
EU contribution
€ 49 375
Address
Francis Street 75
02241 Boston Ma
Activity type
Research Organisations