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Improving Diagnosis by Fast Field-Cycling MRI

Objective

Many diseases are inadequately diagnosed, or not diagnosed early enough by current imaging methods. Examples of unmet clinical needs arise in thromboembolic disease, osteoarthritis, cancer, sarcopenia, and many more areas. Our solution, Fast Field-Cycling (FFC) MRI, can measure quantitative information that is invisible to standard MRI. FFC scanners switch magnetic field while scanning the patient, obtaining new diagnostic information. FFC-MRI has been demonstrated by us, but many challenges must be solved before clinical adoption.
Objectives:
Understand the mechanisms determining FFC signals in tissues;
Create technology to measure and correct for environmental magnetic fields, enabling FFC at ultra-low fields;
Investigate contrast agents for FFC, to increase sensitivity and to allow molecular imaging;
Improve FFC technology, in order to extend its range of clinical applications;
Test FFC-MRI on tissue samples and on patients.
Achieved by:
Developing the theory of relaxation in tissue at ultra-low fields, leading to models and biomarkers;
Developing magnetometers for FFC-MRI, and environmental-field correction;
Creating and in vitro testing of new FFC contrast agents; studying existing clinical agents for FFC-MRI sensitivity;
Improving technology to monitor and stabilise magnetic fields in FFC; improving magnet power supply stability; investigating better radiofrequency coils and acquisition pulse sequences;
Testing FFC methods on tissue samples from surgery and tissue banks; proof-of-principle scans on patients.
FFC-MRI is a paradigm-shifting technology which will generate new, quantitative disease biomarkers, directly informing and improving clinical diagnosis, treatment decisions and treatment monitoring. Its lower cost contributes to healthcare sustainability. The proposal consolidates the EU lead in FFC technology and uses new concepts from world-leading teams to deliver solutions based on innovations in theory, modelling, physics, chemistry and engineering.

Call for proposal

H2020-PHC-2014-2015

See other projects for this call

Sub call

H2020-PHC-2015-two-stage

Coordinator

UNIVERSITY OF ABERDEEN
Net EU contribution
€ 1 479 853,75
Address
King's College Regent Walk
AB24 3FX Aberdeen
United Kingdom

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Region
North Eastern Scotland Aberdeen City and Aberdeenshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 479 853,75

Participants (11)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 633 625,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 633 625,00
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Net EU contribution
€ 1 173 041,25
Address
Rue Leblanc 25
75015 Paris 15

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 1 173 041,25
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 278 307,50
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 278 307,50
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT POLYTECHNIQUE DE GRENOBLE
France
Net EU contribution
€ 68 437,50
Address
Avenue Felix Viallet 46
38031 Grenoble Cedex 1

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Higher or Secondary Education Establishments
Other funding
€ 68 437,50
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE GRENOBLE ALPES
France
Net EU contribution
€ 20 815,00
Address
621 Avenue Centrale
38058 Grenoble

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Higher or Secondary Education Establishments
Other funding
€ 20 815,00
UNIVERSITA DEGLI STUDI DI TORINO
Italy
Net EU contribution
€ 584 750,00
Address
Via Giuseppe Verdi 8
10124 Torino

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Region
Nord-Ovest Piemonte Torino
Activity type
Higher or Secondary Education Establishments
Other funding
€ 584 750,00
UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE
Poland
Net EU contribution
€ 321 000,00
Address
Ul. Oczapowskiego 2
10 719 Olsztyn

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Region
Makroregion północny Warmińsko-mazurskie Olsztyński
Activity type
Higher or Secondary Education Establishments
Other funding
€ 321 000,00
TECHNISCHE UNIVERSITAET ILMENAU
Germany
Net EU contribution
€ 442 250,00
Address
Ehrenbergstrasse 29
98693 Ilmenau

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Region
Thüringen Thüringen Ilm-Kreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 442 250,00
STELAR SRL
Italy
Net EU contribution
€ 902 750,00
Address
Via Enrico Fermi 4
27035 Mede

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Ovest Lombardia Pavia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 902 750,00
INTERNATIONAL ELECTRIC COMPANY OY

Participation ended

Finland
Net EU contribution
€ 255 466,25
Address
Sahaajankatu 48
00880 Helsinki
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 255 466,25
OY INTERNATIONAL ELECTRIC COMPANY
Finland
Net EU contribution
€ 437 081,25
Address
Sahaajankatu 48
00880 Helsinki

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 437 081,25