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INtestinal Tissue ENgineering Solution

Objective

Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children and adults who have lost their bowel. PN offers a low survival rate, compromised quality of life, and the economic cost for each patient is estimated to be 55,000 euro/year. Small intestinal transplant is also an option with one-year and 4-year survival rates of 90% and 60% respectively. However, because of the shortage of organs, high mortality, the severe side effects of immunosuppression and low quality of life, this is still a sub-optimal solution.
The objective of this programme is to deliver a functional bowel reconstruction to patients with SBS through an autologous tissue engineering strategy, overcoming the shortage of organs, and avoiding the need for immunosuppression. It will be achieved by identifying the best autologous cell source; providing the ideal scaffold; engineering functional intestine for transplantation and engaging with patients, scientists and public. The work is designed to lead directly to a clinical trial for the application of the optimal protocol for tissue-engineered intestine. The consortium is uniquely positioned to complete this ambitious effort as we have an internationally pre-eminent, multi-disciplinary team, which possesses a combination of expertise from basic molecular biology, engineering, and surgery, combining knowledge from universities, hospitals and industry. Importantly we are one of the few groups in the world with experience, infrastructure, and track record to translate regenerative medicine solutions to patients, including true clinical translation of tissue engineered organs.

Field of science

  • /medical and health sciences/clinical medicine/surgery
  • /medical and health sciences/medical biotechnology/tissue engineering
  • /medical and health sciences/clinical medicine/transplantation
  • /natural sciences/biological sciences/molecular biology
  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/health sciences/nutrition

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITY COLLEGE LONDON
Address
Gower Street
WC1E 6BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 300 713

Participants (8)

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
EU contribution
€ 825 625
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Activity type
Other
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 921 160
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
EU contribution
€ 682 163
Address
1 Midland Road
NW1 1AT London
Activity type
Research Organisations
STEMCELL TECHNOLOGIES UK LTD
United Kingdom
EU contribution
€ 629 495
Address
Building 7100 Cambridgde Research Park Beach Drive Waterbeach
CB25 9TL Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 0
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 720 000
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
CHILDREN'S HOSPITAL LOS ANGELES
United States
EU contribution
€ 810 775
Address
4650 Sunset Boulevard, Ms 97
90027 6062 Los Angeles,ca
Activity type
Other
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 100 533
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments