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Children’s Liver Tumour European Research Network

Objective

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying cirrhotic liver diseases. The ChiLTERN project relates to topic PHC 18 ‘establishing effectiveness of health care interventions in the paediatric population’. The ChiLTERN project builds on a unique opportunity to undertake a comprehensive research programme linked to an ambitious global partnership which will see the single largest clinical trial (the Paediatric Hepatic International Tumour Trial - PHITT) ever undertaken in this population of patients, with several randomised questions in six subgroups of patients. ChiLTERN will allow us to move towards an era of personalised therapy in which each patient will receive the correct amount of chemotherapy and will undergo has the best surgical operation (surgical resection or liver transplant). By using both clinical and biological information, we can assign patients more accurately to risk groups based on their survival. Using genetic tests and biomarkers, we will determine those children who may be at risk of developing long term side effects (deafness, heart failure, kidney damage). In addition, biomarkers will allow us to monitor during therapy and detect toxicities early before serious damage is done so that we can adapt treatment and prevent these problems. Finally, we will be using imaging technology tools which will help our surgeons plan liver operations more safely and effectively. Ultimately ChiLTERN will allow us to cure more children with liver cancer, expose fewer children to toxic chemotherapy and ensure their surgery is both effective and safe.
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Coordinator

THE UNIVERSITY OF BIRMINGHAM

Address

Edgbaston
B15 2tt Birmingham

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 127 320,75

Participants (22)

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CINECA CONSORZIO INTERUNIVERSITARIO

Italy

EU Contribution

€ 281 250

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

EU Contribution

€ 87 655

CLINIQUES UNIVERSITAIRES SAINT-LUC

Belgium

EU Contribution

€ 236 402,25

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

EU Contribution

€ 105 625

SCHWEIZERISCHE PADIATRISCHE ONKOLOGIE GRUPPE (SPOG)

Switzerland

SERVICIO ANDALUZ DE SALUD

Spain

EU Contribution

€ 187 575

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

EU Contribution

€ 406 250

GDANSKI UNIWERSYTET MEDYCZNY

Poland

EU Contribution

€ 181 425

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 702 250

UNIVERSITATSKLINIKUM BONN

Germany

EU Contribution

€ 230 500

XENTECH SAS

France

EU Contribution

€ 26 250

CENTRE HOSPITALIER UNIVERSITAIRE DE RENNES

France

EU Contribution

€ 472 356

INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL

Spain

EU Contribution

€ 990 456

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

Germany

EU Contribution

€ 121 875

OSLO UNIVERSITETSSYKEHUS HF

Norway

EU Contribution

€ 107 387,50

AZIENDA OSPEDALIERA DI PADOVA

Italy

EU Contribution

€ 177 275

VASTRA GOTALANDS LANS LANDSTING

Sweden

EU Contribution

€ 117 825

OUR LADYS CHILDRENS HOSPITAL CRUMLIN

Ireland

EU Contribution

€ 92 262,50

FAKULTNI NEMOCNICE V MOTOLE

Czechia

EU Contribution

€ 36 725

MEVIS MEDICAL SOLUTIONS AG

Germany

EU Contribution

€ 75 000

ISTITUTO DI RICERCA PEDIATRICA CITTA DELLA SPERANZA

Italy

EU Contribution

€ 130 000

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV

Netherlands

EU Contribution

€ 48 000

Project information

Grant agreement ID: 668596

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 December 2020

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 8 191 665

  • EU contribution

    € 7 941 665

Coordinated by:

THE UNIVERSITY OF BIRMINGHAM

United Kingdom