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Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy

Objective

Alcohol addiction ranks among the primary global causes of preventable death and disabilities in human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Within this project, we will utilize a translational approach based on clinical studies and animal experiments to fill this gap. We will provide a novel discovery strategy based on systems biology concepts that uses mathematical and network theoretical models to identify brain sites and functional networks that can be targeted specifically by therapeutic interventions. To build predictive models of the ‘relapse-prone’ state of brain networks we will use magnetic resonance imaging and neurochemical data from patients and laboratory animals. The mathematical models will be rigorously tested through experimental procedures aimed to guide network dynamics towards increased resilience. We expect to identify hubs that promote ‘relapse-proneness’ and to predict how aberrant network states could be normalized. Proof of concept experiments in animal will need to demonstrate this possibility by showing directed remodeling of functional brain networks by targeted interventions prescribed by the theoretical framework. Thus, our translational goal will be achieved by a theoretical and experimental framework for making predictions based on fMRI and mathematical modeling, which is verified in animals, and which can be transferred to humans. To achieve this goal we have assembled an interdisciplinary consortium (eight European countries) of world-class expertise in all complementary skills required for the project. If successful this project will positively impact on the development of new therapies for a disorder with largely unmet clinical needs, and thus help to address a serious and widespread health problem in our societies.
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Coordinator

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Address

Square J 5
68159 Mannheim

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 861 352,50

Participants (14)

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THE UNIVERSITY OF SUSSEX

United Kingdom

EU Contribution

€ 449 943,75

LINKOPINGS UNIVERSITET

Sweden

EU Contribution

€ 416 625

BEN-GURION UNIVERSITY OF THE NEGEV

Israel

EU Contribution

€ 259 252,50

OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG

Germany

INSTITUTUL ROMAN DE STIINTA SI TEHNOLOGIE

Romania

EU Contribution

€ 227 826,25

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 161 140

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italy

EU Contribution

€ 389 791,25

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 448 258,75

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 408 687,50

METANOMICS HEALTH GMBH

Germany

BRAIN RESEARCH AND DEVELOPMENT SERVICES LTD

Israel

EU Contribution

€ 150 747,50

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 550 000

UNIVERSITEIT LEIDEN

Netherlands

EU Contribution

€ 250 000

ASOCIATIA TRANSYLVANIAN INSTITUTE OF NEUROSCIENCE

Romania

EU Contribution

€ 186 298,75

Project information

Grant agreement ID: 668863

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 December 2019

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 5 759 923,75

  • EU contribution

    € 5 759 923,75

Coordinated by:

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Germany