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Understanding asthma phenotypes: going beyond the atopic/non-atopic paradigm

Objective

Fifteen years ago it was widely believed that asthma was an allergic/atopic disease caused by allergen exposure in infancy; this produced atopic sensitization and continued exposure resulted in eosinophilic airways inflammation, bronchial hyper-responsiveness and reversible airflow obstruction. It is now clear that this model is at best incomplete. Less than one-half of asthma cases involve allergic (atopic) mechanisms, and most asthma in low-and-middle income countries is non-atopic. Westernization may be contributing to the global increases in asthma prevalence, but this process appears to involve changes in asthma susceptibility rather than increased exposure to “established” asthma risk factors. Understanding why these changes are occurring is essential in order to halt the growing global asthma epidemic.This will require a combination of epidemiological, clinical and basic science studies in a variety of environments.

A key task is to reclassify asthma phenotypes. These are important to: (i) better understand the aetiological mechanisms of asthma; (ii) identify new causes; and (iii) identify new therapeutic measures. There are major opportunities to address these issues using new techniques for sample collection from the airways (sputum induction, nasal lavage), new methods of analysis (microbiome, epigenetics), and new bioinformatics methods for integrating data from multiple sources and levels. There is an unprecedented potential to go beyond the old atopic/non-atopic categorization of phenotypes.

I will therefore conduct analyses to re-examine and reclassify asthma phenotypes. The key features are the inclusion of: (i) both high and low prevalence centres from both high income countries and low-and-middle income countries; (ii) much more detailed biomarker information than has been used for previous studies of asthma phenotypes; and (iii) new bioinformatics methods for integrating data from multiple sources and levels.

Call for proposal

ERC-2014-ADG
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Funding Scheme

ERC-ADG - Advanced Grant

Host institution

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
Address
Keppel Street
WC1E 7HT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 067 832

Beneficiaries (6)

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 1 067 832
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE FEDERAL DA BAHIA
Brazil
EU contribution
€ 255 882
Address
Rua Augusto Vianna Sn Canela
40110-060 Salvador
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 269 141
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 255 880
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
UNITED KINGDOM RESEARCH AND INNOVATION

Participation ended

United Kingdom
EU contribution
€ 30 093
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
Massey University
New Zealand
EU contribution
€ 469 975
Address
Tennent Drive
4442 Palmerston North
Activity type
Higher or Secondary Education Establishments