CORDIS
EU research results

CORDIS

English EN
Understanding asthma phenotypes: going beyond the atopic/non-atopic paradigm

Understanding asthma phenotypes: going beyond the atopic/non-atopic paradigm

Objective

Fifteen years ago it was widely believed that asthma was an allergic/atopic disease caused by allergen exposure in infancy; this produced atopic sensitization and continued exposure resulted in eosinophilic airways inflammation, bronchial hyper-responsiveness and reversible airflow obstruction. It is now clear that this model is at best incomplete. Less than one-half of asthma cases involve allergic (atopic) mechanisms, and most asthma in low-and-middle income countries is non-atopic. Westernization may be contributing to the global increases in asthma prevalence, but this process appears to involve changes in asthma susceptibility rather than increased exposure to “established” asthma risk factors. Understanding why these changes are occurring is essential in order to halt the growing global asthma epidemic.This will require a combination of epidemiological, clinical and basic science studies in a variety of environments.

A key task is to reclassify asthma phenotypes. These are important to: (i) better understand the aetiological mechanisms of asthma; (ii) identify new causes; and (iii) identify new therapeutic measures. There are major opportunities to address these issues using new techniques for sample collection from the airways (sputum induction, nasal lavage), new methods of analysis (microbiome, epigenetics), and new bioinformatics methods for integrating data from multiple sources and levels. There is an unprecedented potential to go beyond the old atopic/non-atopic categorization of phenotypes.

I will therefore conduct analyses to re-examine and reclassify asthma phenotypes. The key features are the inclusion of: (i) both high and low prevalence centres from both high income countries and low-and-middle income countries; (ii) much more detailed biomarker information than has been used for previous studies of asthma phenotypes; and (iii) new bioinformatics methods for integrating data from multiple sources and levels.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Host institution

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER

Address

Keppel Street
Wc1e 7ht London

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 269 332

Beneficiaries (7)

Sort alphabetically

Sort by EU Contribution

Expand all

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER

United Kingdom

EU Contribution

€ 1 269 332

UNIVERSIDADE FEDERAL DA BAHIA

Brazil

EU Contribution

€ 255 882

UNIVERSITY OF BRISTOL

United Kingdom

EU Contribution

€ 269 141

ST GEORGE'S HOSPITAL MEDICAL SCHOOL

United Kingdom

EU Contribution

€ 255 880

UNITED KINGDOM RESEARCH AND INNOVATION

United Kingdom

EU Contribution

€ 30 093

MEDICAL RESEARCH COUNCIL

United Kingdom

Massey University

New Zealand

EU Contribution

€ 268 475

Project information

Grant agreement ID: 668954

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 December 2020

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 348 803

  • EU contribution

    € 2 348 803

Hosted by:

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER

United Kingdom