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Genetics and function of neuronal circuits controlling goal oriented movements

Objective

With this proposal I plan to dissect, at the genetic level, those circuits controlling goal-oriented movements in mice. In particular, we will focus on the very feature that makes goal-oriented movements so unique in the world of motor control, the spatial awareness of such movements, the fact that their execution is likely to obey a precise metric. I want to understand: (1) which neuronal circuits promote the initiation of targeted-movement and assess the genetic heterogeneity of these circuits. (2) Characterise the function of genetically identified circuit elements during movement execution, with the aim of understanding how the metric of motion is encoded. (3) Investigate how sensory maps and motor maps are aligned during development and probe their plasticity. In prospective (4), we aim to understand how changes in such circuits impinge on the development and evolution of innate behaviours such as predation.
The French mathematician Henry Poincaré wrote that ‘The real space is motor space’. Embedded in this idea is the intimate relation between the perceptual encoding of space and motor execution. Accordingly, our research starts at the motor level and aims to move to the perceptual level.

Host institution

UNITED KINGDOM RESEARCH AND INNOVATION
Net EU contribution
€ 1 495 731,00
Address
Polaris House North Star Avenue
SN2 1FL Swindon
United Kingdom

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Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Beneficiaries (1)

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom
Net EU contribution
€ 1 495 731,00
Address
Polaris House North Star Avenue
SN2 1FL Swindon

See on map

Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon
Activity type
Research Organisations
Non-EU contribution
€ 0,00