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Laser and Ultrasound Co-Analyzer for thyroid nodules

Laser and Ultrasound Co-Analyzer for thyroid nodules

Objective

This is a trans-disciplinary project that joins endocrinologists (“end-users”), radiologists (“end-users”), physicists who are
experts in medical photonics, engineers who are experts in photonics and ultrasonics and the industry to work towards a
concentrated goal - to produce a novel, point-of-care, low-cost, screening device that combines two photonics systems
(near-infrared diffuse correlation spectroscopy (DCS) and time-resolved spectroscopy (TRS)) with a multi-modal ultrasound
(US) system and a probe that enables multi-modal data acquisition for the screening of thyroid nodules (TN) for thyroid
cancer (TC). TN are a common pathology having a prevalence of palpable nodules around 5% in women and 1% in men,
that increases to 19-76% with the use of neck US. In screening thyroid nodules, to exclude thyroid cancer which occurs in
5-15% of TN, the first step is the US followed by fine needle aspiration biopsy (FNAB) of suspicious nodules. The sensitivity
and specificity of this process in thyroid cancer are limited, with a large number of non-diagnostic and false positive results
that lead to unnecessary surgeries. A reduction in the number of surgeries with a point-of-care diagnostic procedure would
have an important socio-economic impact, diminishing the number of thyroidectomies and the associated comorbidities. This
implies savings of millions of euros per year. Evidence shows that multi-modal approaches that include hemodynamic
information leads to better specificity while each modality on its own fails. We hypothesize that a new optical-ultrasound
probe and integrated system enabled by the development of novel, key enabling photonic components and sub-systems to
provide synergetic information on tissue morphology, composition and function will have a large impact in this field. Our
action is directed by end-users who participate in the proposal and will be exploited by the industrial partners who cover the
whole value-chain.
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Coordinator

FUNDACIO INSTITUT DE CIENCIES FOTONIQUES

Address

Avinguda Carl Friedrich Gauss 3
08860 Castelldefels

Spain

Activity type

Research Organisations

EU Contribution

€ 986 230

Participants (7)

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POLITECNICO DI MILANO

Italy

EU Contribution

€ 689 700

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

EU Contribution

€ 353 763,75

HEMOPHOTONICS SL

Spain

EU Contribution

€ 464 800

VERMON SA

France

EU Contribution

€ 188 630,75

IMV IMAGING FRANCE

France

EU Contribution

€ 273 542,50

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

EU Contribution

€ 297 178,75

EIBIR GEMEINNUETZIGE GMBH ZUR FOERDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG

Austria

EU Contribution

€ 375 000

Project information

Grant agreement ID: 688303

Status

Ongoing project

  • Start date

    1 February 2016

  • End date

    31 January 2020

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 4 026 120

  • EU contribution

    € 3 628 845,75

Coordinated by:

FUNDACIO INSTITUT DE CIENCIES FOTONIQUES

Spain