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COMPACT BIOPHOTONIC PLATFORM FOR DRUG ALLERGY DIAGNOSIS

COMPACT BIOPHOTONIC PLATFORM FOR DRUG ALLERGY DIAGNOSIS

Objective

Drug hypersensitivity to antibiotics, mainly Beta-lactams (BLCs) affects more than 2.5 million European citizens. Moreover, preventable adverse drug reactions are estimated in additional hospitalization costs of 1750-4500 €/patient. Currently, the allergy diagnosis is mainly based on the information given by invasive, single, and risky in vivo assays. In daily practice, few in vitro diagnostic methods are available and only used at the tertiary health services. These tests also lack of sensitivity (>0.35 kUA/L) and selectivity (<98%), resulting in an inaccurate diagnosis, analyze few drugs allergens (5), are time consuming (60-180 min), and expensive (30 €/allergen).

COBIOPHAD aims the development of an innovative in vitro diagnostic (IVD) device for diagnosis of IgE-mediated drug allergies by building an integrated biophotonic system based on compact disc technology. For that, key enabling technologies will be integrated in order to achieve high sensitive (<0.1 kUA/L), selective (>98%), multiplexed (10 BLCs), rapid (30 min), and low-cost (2.4 €/allergen) drug allergy test. The solution involves an advanced approach to the diagnosis and management of drug allergy with the aim to ameliorate patient safety.

The consortium comprises multidisciplinary knowledge on optics, electronics, advanced materials, biotechnology, smart microstructures, microfluidics, surface/organic chemistry, allergy, manufacturing systems, and telecom networking. Also, the key industrial actors, present in the consortium, will contribute to the manufacturing and placing the product on the IVD market.
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Coordinator

UNIVERSITAT POLITECNICA DE VALENCIA

Address

Camino De Vera Sn Edificio 3a
46022 Valencia

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 026 678,75

Participants (12)

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BIOTRONICS 3D LIMITED

United Kingdom

EU Contribution

€ 211 596,88

CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER

France

EU Contribution

€ 451 932

EUREXPLOIT LTD

United Kingdom

EU Contribution

€ 153 128,50

DR. FOOKE-ACHTERRATH LABORATORIEN GMBH

Germany

EU Contribution

€ 314 978,13

FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA

Spain

EU Contribution

€ 364 687

OPTOELECTRONICA - 2001 SA

Romania

EU Contribution

€ 159 300,75

STIFTELSEN SINTEF

Norway

EU Contribution

€ 462 945

SONY DADC AUSTRIA

Austria

EU Contribution

€ 32 373,25

DAS PHOTONICS SL

Spain

EU Contribution

€ 38 854,27

STRATEC CONSUMABLES GMBH

Austria

EU Contribution

€ 304 097,88

LUMENSIA SENSORS SL

Spain

EU Contribution

€ 76 733,23

SINTEF AS

Norway

EU Contribution

€ 137 475

Project information

Grant agreement ID: 688448

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 July 2019

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 4 288 094,19

  • EU contribution

    € 3 734 780,64

Coordinated by:

UNIVERSITAT POLITECNICA DE VALENCIA

Spain